Keinapten Tablet (Thianaprine Sodium)

Adult dose

○ Adults : Administer 12.5 mg of tianeptine sodium orally before meals 3 times daily. ○ For elderly patients aged 70 years or older or patients with renal impairment, limit administration to 2 times daily. ○ Adjust the dose as appropriate according to symptoms. ○ Abrupt discontinuation of treatment should be avoided. To reduce the risk of withdrawal reactions, the dose should be gradually reduced over 7 ~ 14 days. (See “General Precautions” under Precautions for Use.)

This medicine is used for the treatment of depression, and during the initial weeks of treatment, symptoms may not improve, requiring careful monitoring of the patient. Especially, patients at high risk of suicide require closer observation at the start of treatment and when adjusting the dose. This medication should not be administered to children under 15 years of age, patients with certain genetic disorders, or patients taking certain medications. Various side effects such as loss of appetite, nightmares, insomnia, drowsiness, dizziness, palpitations, and gastrointestinal disturbances may occur during treatment, so attention should be paid to symptoms. Before surgery, inform the anesthesiologist about the use of this drug, and, if necessary, cessation of medication should be discussed, and it is advisable not to take it with alcohol. Withdrawal symptoms may occur upon discontinuation of the drug, so the dose should be gradually reduced according to the doctor's instructions. Caution is required when driving or operating machinery due to possible drowsiness or reduced attention. Patients with impaired renal function or the elderly may require dose adjustments, and caution is necessary regarding the possibility of electrolyte disturbances such as hyponatremia. Use during pregnancy is not recommended, and breastfeeding should also be avoided. In case of overdose, immediately visit a medical institution for appropriate treatment. It is safe to keep this medication out of the reach of children and not to transfer it to other containers.

• Loss of appetite
• hyponatremia
• nightmares
• drug abuse and dependence
• suicidal thoughts
• suicidal behaviors
• confusion
• hallucinations
• insomnia
• drowsiness

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. It is advisable to maintain the storage temperature between 1 to 30 degrees Celsius at room temperature. This will help to preserve the effectiveness of the medication.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle