Olgotan Tablet 20mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose is 10mg once daily, irrespective of meals. If blood pressure is not adequately controlled at this dose, it may be increased to 20mg once daily, and can be up to a maximum of 40mg daily. The blood pressure-lowering effect usually occurs within 2 weeks of starting treatment, with maximum effect reached in about 8 weeks. If blood pressure remains uncontrolled, this medication may be used in combination with thiazide diuretics. To improve adherence, patients are encouraged to take the medication at the same time each day (e.g., in the morning). In patients at risk of intravascular volume depletion (e.g., those on diuretics, especially with kidney dysfunction), starting treatment at a low dose while sufficiently monitoring their condition is recommended. <Elderly> When administering this medication to patients aged 65 years and older, dose adjustment is not necessary. No overall differences in efficacy and safety have been observed between elderly and younger patients, but heightened sensitivity may be possible in some elderly patients. <Renal impairment> For patients with mild to moderate renal impairment (creatinine clearance of 20-60mL/min), the maximum dosing recommendation is 20mg once daily. <Liver impairment> Patients with mild liver impairment do not require dose adjustment. The recommended initial dose for patients with moderate liver impairment is 10mg once daily, which can be increased up to a maximum of 20mg daily. Experience in severely impaired liver function patients is lacking, so use in such patients is not recommended. <Pediatric> Safety and efficacy in pediatric patients have not been established.

Child dose

Safety and efficacy in pediatric patients have not been established.

This medication can cause severe harm or death to a fetus or newborn if taken during the second and third trimesters of pregnancy, therefore it should be stopped immediately upon confirmation of pregnancy. Individuals with allergies to this medication or its components, those who are pregnant or breastfeeding, patients undergoing kidney dialysis, those with severe liver dysfunction, patients with bile duct obstruction, and individuals with lactose intolerance should not take this medication. Patients with reduced blood volume or sodium levels, those with impaired kidney function, patients with renal artery hypertension, those at risk of hyperkalemia, patients with aortic or mitral stenosis, and patients with primary aldosteronism should use this medication with caution and be closely monitored at the onset of treatment. Side effects may include dizziness, headache, abdominal pain, nausea, chest pain, and peripheral edema; there may be rare cases of angioedema or liver function abnormalities. Chronic diarrhea and weight loss similar to chronic malabsorption syndrome have been reported; if such symptoms occur, discontinue the medication immediately and consult a doctor. This medication may cause the blood potassium levels to rise dangerously when taken with potassium-sparing diuretics or potassium supplements, so caution is necessary, and it may increase the blood pressure-lowering effect when used with other antihypertensives. If taken with lithium preparations, the serum lithium levels may increase, leading to toxicity, thus concomitant use is not recommended. Taking this medication with non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of kidney function deterioration; kidney function should be regularly monitored during treatment. This medication should not be taken during pregnancy, especially in the second and third trimesters, and breastfeeding should be discontinued or the medication should be stopped, as adverse reactions may occur in infants. Safety and efficacy in pediatric patients have not been established, so it is not recommended for use in children. In elderly patients, due to the possibility of elevated serum drug concentrations, dose adjustment and careful monitoring are required. In cases of overdose, symptoms such as hypotension, palpitations, and bradycardia may occur, and immediate medical attention is necessary.

Serious side effects

Hives, angioedema, anaphylaxis, intestinal angioedema, hyperkalemia, acute renal failure, increased serum creatinine, liver function abnormalities (increased liver enzymes or bilirubin), hives, facial swelling, peripheral edema, asthma, chest pain

Mild side effects

• Dizziness
• headache
• palpitations
• hypercholesterolemia
• hyperlipidemia
• hyperuricemia
• arthralgia
• arthritis
• myalgia
• rash

This medication is sensitive to air and humidity, so it should be stored in a tightly sealed container. Additionally, it should be kept at room temperature between 1 to 25 degrees Celsius, away from extremes of heat or cold, to maintain its effectiveness for a longer period.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle