Presaltan Plus Tablet 20/12.5 mg (Olmesartan Medoxomil, Hydrochlorothiazide)

Adult dose

This medication is administered as one tablet once daily regardless of meals after adjusting the dose of Olmesartan Medoxomil or Hydrochlorothiazide alone. The dosage should be adjusted at intervals of 2 to 4 weeks based on the patient’s blood pressure response. For elderly patients, starting from the lowest dose is recommended, taking into account the patient’s kidney function, heart function, comorbid conditions, and concomitant medications.

Child dose

Safety and efficacy in pediatric patients have not been established, so its use is not recommended.

This drug may cause serious harm or death to the fetus and newborn if taken during the second and third trimesters of pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Patients with allergies to any of the ingredients in this medication or those who are hypersensitive to thiazide diuretics or sulfonamide drugs should not take this medication. Patients with specific conditions such as acute kidney injury, severe liver disease, bile duct obstruction, hyponatremia, hypokalemia, hypercalcemia, or Addison's disease should not be administered this medication. Patients with decreased blood volume or salt may experience hypotension during the initial phase of taking this medication, so they should be closely monitored, and appropriate actions should be taken if hypotension occurs. Patients with impaired renal function or those who have had a kidney transplant should regularly check serum potassium and creatinine levels, and caution is also required in patients with renovascular hypertension or liver disease. This medication may increase the risk of skin cancer, so it is advisable to limit sun exposure and consult a doctor immediately if any skin abnormalities occur. Dizziness or drowsiness may occur while taking this medication, so it is advisable to avoid driving or operating hazardous machinery. This medication may interact with other medications, so especially for those taking potassium supplements, lithium, non-steroidal anti-inflammatory drugs, or other antihypertensives, it is essential to consult a doctor or pharmacist. If breastfeeding, it is recommended to discontinue breastfeeding or this medication, as it may be transmitted through breast milk and affect the baby. Safety and effectiveness in pediatric patients have not been established, so it is advisable not to use it in children. For the elderly, it is safer to start from a low dose considering the decline in liver, kidney, and heart function and concomitant medications. In case of overdose, hypotension, electrolyte abnormalities, dehydration, etc., may occur, so immediate medical attention should be sought.

Serious side effects

• Urticaria, severe swelling (edema), angioedema, anaphylaxis, severe allergic reaction
• Severe rash with high fever, blistering, skin peeling, pain in oral/ocular mucosa, Stevens-Johnson syndrome, erythema multiforme, exfoliative dermatitis, toxic epidermal necrolysis, severe skin adverse reaction
• Shortness of breath or difficulty breathing, pulmonary edema, acute respiratory distress syndrome (ARDS), respiratory issues
• Jaundice (yellowing of the skin or eyes), hepatitis, liver abnormalities

Mild side effects

• Nausea
• dizziness
• upper respiratory infection
• headache
• urinary tract infection
• chest pain
• back pain
• peripheral edema
• abdominal pain
• dyspepsia

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, and it is best stored at room temperature between 1 and 25 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a long time.

Appearance

Round, film-coated tablet with a light orange color

Package unit

30 tablets/bottle, 100 tablets/bottle