Olmefant Table 10mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose for adults is 10 mg once daily, regardless of meals. If blood pressure is not adequately controlled at this dose, it can be increased to 20 mg once daily, with a maximum increase to 40 mg per day. The blood pressure-lowering effect typically appears within 2 weeks after starting treatment, with maximum effect occurring around 8 weeks. If blood pressure is not adequately lowered, it may be combined with thiazide diuretics. For the elderly (65 years and older), dose adjustment is not required. While no overall differences in efficacy and safety between older and younger patients have been observed, some older adults may have a more sensitive response. For patients with renal impairment, the maximum dosing for mild to moderate renal impairment (creatinine clearance 20-60 mL/min) is 20 mg once daily. For patients with liver impairment, mild liver impairment does not require dose adjustment. For moderate liver impairment, the recommended initial dose is 10 mg once daily, which can be increased to a maximum of 20 mg per day. There is no experience concerning the use in severe liver impairment, hence its use is not recommended.

Child dose

Safety and efficacy have not been established for pediatric populations.

This medication may cause severe harm or even death to the fetus and neonate when administered to pregnant women in the second and third trimesters, hence, it should be discontinued immediately upon confirmation of pregnancy. People who are allergic to this medication or its components, pregnant or breastfeeding women, patients undergoing renal dialysis, those with severe liver impairment, patients with biliary obstruction, and individuals with lactose intolerance should not use this medication. Patients with reduced blood volume or low sodium levels may experience hypotension, therefore, their condition should be checked thoroughly before beginning treatment, and appropriate measures should be taken immediately if hypotension occurs. Patients with impaired renal function or kidney transplant recipients should have their renal function and electrolyte status regularly monitored through blood tests, and it is not recommended for patients with severe renal impairment. Since this medication lowers blood pressure, patients with aortic stenosis or hypertrophic obstructive cardiomyopathy should use it with caution, and dizziness might occur due to blood pressure reduction, hence driving or operating dangerous machinery should be avoided. Side effects such as dizziness, headaches, chest pain, dyspepsia, muscle pain, and rash may occur during the course of treatment, and, although rare, angioedema or liver function abnormalities may also arise. If chronic diarrhea and weight loss persist, this medication may be responsible, and immediate consultation with healthcare professionals is needed; if intestinal angioedema symptoms appear, discontinue use and seek appropriate treatment. Co-administration of potassium-sparing diuretics or potassium supplements may cause dangerously high potassium levels, thus potassium levels should be regularly monitored through blood tests when used together. Additionally, co-administration with lithium or non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of side effects, so healthcare providers must be notified. During pregnancy, especially, there are risks of fetal renal function reduction and amniotic fluid decrease, so it's safer not to use this medication if pregnancy is planned or possible. In breastfeeding, this medication may be partially transferred to breast milk and can cause adverse reactions in infants, hence it's recommended to discontinue either breastfeeding or this medication. Safety has not been established in pediatric populations, so it should not be used in children. Overdosage may cause symptoms such as hypotension and palpitations, so if these symptoms occur, immediate medical attention should be sought for appropriate treatment.

Serious side effects

Urticaria, angioedema, facial swelling, anaphylaxis, severe edema, hyperkalemia, acute renal failure, elevated serum creatinine, liver function abnormalities (increased liver enzymes or bilirubin levels), asthma, increased blood pressure, chronic malabsorption syndrome, intestinal angioedema, rhabdomyolysis

Mild side effects

• Dizziness
• headaches
• palpitations
• low back pain
• hematuria
• hyperglycemia
• hypertriglyceridemia
• flu-like symptoms
• pharyngitis
• rhinitis

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain room temperature between 1 and 25 degrees Celsius to preserve the efficacy and safety of the medication.

Appearance

White round film-coated tablet

Package unit

30 tablets per bottle