Olcotan Tablet 10mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose is 10mg once daily, taken regardless of meal. If blood pressure is not adequately controlled, it may be increased to 20mg once daily. If further blood pressure reduction is needed, it may be increased up to a maximum of 40mg once daily. The antihypertensive effect appears within 2 weeks after starting treatment and reaches its maximum effect around 8 weeks. If blood pressure is not controlled with this medication alone, it may be taken in combination with thiazide diuretics such as hydrochlorothiazide. To improve adherence, it is recommended to take it around the same time every day (e.g., in the morning). For patients at risk of intravascular volume depletion (e.g., patients on diuretics, especially those with kidney impairment), treatment should start at a low dose with careful monitoring of their condition.

Child dose

Safety and efficacy in children have not been established.

This medication can cause serious harm to the fetus and newborn if taken during the second and third trimesters of pregnancy, thus it should be discontinued immediately upon confirmation of pregnancy. Patients with hypersensitivity to the components of this medication, pregnant and breastfeeding women, patients on kidney dialysis, those with severe liver impairment, patients with biliary obstruction, specific genetic lactose intolerance, and certain diabetes patients should not use this medication. Patients with reduced blood volume or salt may experience hypotension, so careful monitoring and appropriate measures are necessary before administering this medication. Patients with impaired kidney function or those who have received a kidney transplant should have their kidney function and serum potassium levels regularly monitored, and it is not recommended for those with severe kidney impairment. This medication may cause hyperkalemia, so patients with heart failure or kidney disorders should carefully monitor their serum potassium levels. Patients with aortic or mitral stenosis, obstruction, and hypertrophic cardiomyopathy require special caution. Dizziness may occur due to blood pressure-lowering effects, so caution should be exercised during high-risk activities such as working at heights or driving. Mild and transient side effects such as dizziness, headache, back pain, dyspepsia may occur, and rare reports of angioedema or liver function abnormalities have been noted. Prolonged use may lead to chronic diarrhea and chronic malabsorption-like intestinal diseases, so patients should consult a doctor if intestinal symptoms occur. When taken with potassium-sparing diuretics or potassium supplements, serum potassium levels may increase to dangerous levels, so caution is needed when used in combination. Taking this medication with other antihypertensives may enhance blood pressure-lowering effects, so patients must inform their doctor of other medications they are taking. Combining with lithium may raise serum lithium levels and cause toxicity, therefore this combination is not recommended. Taking with non-steroidal anti-inflammatory drugs may increase the risk of kidney function decline, thus hydration and monitoring of kidney function are necessary. In pregnant women, there is a risk of fetal damage, so this medication should be avoided during pregnancy, and breastfeeding should be discontinued or discussed with a doctor. Safety for children has not been adequately established, so this medication should be administered cautiously to children. Elderly patients may experience increased drug concentration in the body, requiring dose adjustment and caution. In the event of overdose, hypotension and palpitations may occur, and appropriate treatment should be initiated based on symptoms. This medication has been reported to have a low risk of carcinogenicity or genotoxicity; however, rare cellular-level changes have been observed. During the course of this medication, it is important to have regular health check-ups and follow the physician's instructions closely.

Serious side effects

• Urticaria
• angioedema
• anaphylactic reactions
• chest pain
• peripheral edema
• elevated serum creatinine
• abnormal liver function tests
• hyperkalemia
• acute renal failure
• asthma

Mild side effects

• Dizziness
• headache
• palpitations
• back pain
• bronchitis
• increase in creatine phosphokinase
• diarrhea
• hematuria
• hyperglycemia
• hypertriglyceridemia

This medication should be stored in a sealed container to avoid exposure to air or moisture. It is important to keep the storage temperature between 1 and 25 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle