Wiemethan Tablet 20mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose for adults is 10mg once daily, taken regardless of meals. If blood pressure control is insufficient, the dose can be increased to 20mg once daily; if additional blood pressure reduction is needed, the maximum dose can be increased to 40mg once daily. Blood pressure-lowering effects typically appear within two weeks after starting treatment, and maximum effects are observed after about eight weeks. If blood pressure is not adequately controlled with monotherapy, a thiazide diuretic such as hydrochlorothiazide can be combined. To improve compliance, it is recommended to take the medication at the same time every day (e.g., in the morning). For patients who may have intravascular volume depletion (e.g., those receiving diuretics, particularly those with kidney issues), it is advised to start treatment at a lower dose while carefully monitoring their condition. <Elderly> No dose adjustment is required when administering this medication to elderly patients aged 65 and over. No overall differences in efficacy or safety have been observed between elderly and younger patients; however, some elderly patients may exhibit more sensitive responses. <Renal Impairment> The maximum dose for patients with mild to moderate renal impairment (creatinine clearance 20-60mL/min) is 20mg once daily. <Liver Impairment> Mild liver impairment does not require dose adjustment. For patients with moderate liver impairment, the recommended initial dose is 10mg once daily, which can be increased up to a maximum of 20mg daily. There is no experience with severe liver impairment; therefore, the use of this medication is not recommended. <Pediatrics> Safety and efficacy in pediatric patients have not been established.

Child dose

Safety and efficacy in pediatric patients have not been established.

This medication can cause serious harm to the fetus and newborn in the second and third trimesters of pregnancy; therefore, it must be discontinued immediately upon confirmation of pregnancy. Patients with allergies to any ingredients in this medication, those who are pregnant or breastfeeding, patients undergoing kidney dialysis, severe liver dysfunction, bile duct obstruction, and those with genetic issues such as lactose intolerance should not take this medication. Patients with reduced blood volume or salt levels may experience excessively low blood pressure during the initial phase of treatment; thus, their condition needs careful monitoring before and after starting the treatment. This medication may affect kidney function; therefore, patients with impaired kidney function or kidney transplant recipients should have their kidney status and potassium levels regularly checked through blood tests. Patients with kidney vascular issues, those at risk of hyperkalemia, patients with heart valve disease, and those with primary aldosteronism should use this medication with special caution. This drug lowers blood pressure, which may cause dizziness; caution should be exercised when driving or operating hazardous machinery. Some patients may experience mild and transient side effects such as dizziness, headaches, abdominal pain, muscle pain, and rashes. Rarely, angioedema or severe allergic reactions may occur, and if symptoms worsen, immediate medical attention is required. Long-term use of this medication may cause gastrointestinal issues such as chronic diarrhea or malabsorption; hence, if persistent diarrhea or weight loss occurs, the medication should be stopped and consultation with a physician is recommended. Taking potassium-sparing diuretics or potassium supplements together can dangerously elevate blood potassium levels, thus potassium levels should be closely monitored via blood tests when using such medications concurrently. Moreover, concomitant use with lithium or certain nonsteroidal anti-inflammatory drugs may increase the risk of side effects, so it is essential to consult a healthcare provider when taking other medications. Taking this medication during pregnancy can pose a serious risk to the fetus; thus, women planning a pregnancy or who are pregnant should not take this medication and must discontinue it immediately upon confirmation of pregnancy. Women who are breastfeeding should also avoid this medication as it may be passed into breast milk and affect the infant; cessation of breastfeeding or stopping this medication is recommended. Safety and efficacy in pediatric patients have not been established; therefore, it is advisable not to use this medication in children. Elderly patients should use this medication with caution as drug concentration may increase in their bodies; regular monitoring of blood pressure and kidney function is crucial. In case of overdose, excessively low blood pressure or heart rhythm abnormalities may occur; immediate medical attention should be sought if such symptoms arise.

Serious side effects

Urticaria, angioedema, anaphylactic reactions, intestinal angioedema, rhabdomyolysis, hyperkalemia, acute renal failure, elevated serum creatinine, urticaria, angioedema, liver dysfunction (increase in liver enzymes and bilirubin levels), autoimmune hepatitis, severe allergic reactions, severe edema or urinary issues, respiratory issues (including asthma), severe skin reactions

Mild side effects

• Dizziness
• headaches
• palpitations
• lower back pain
• bronchitis
• increased creatine kinase
• diarrhea
• hematuria
• hyperglycemia
• hypertriglyceridemia

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is best to store it at room temperature between 1 degree and 25 degrees Celsius. Proper storage can help maintain the drug's effectiveness for a longer duration.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle