Olmesartan Medoxomil 20 mg Tablet

Adult dose

The recommended initial dose is 10 mg once daily, administered regardless of meals. If blood pressure is not adequately controlled at this dose, it may be increased to 20 mg once daily. For cases requiring additional blood pressure reduction, the maximum dose can be increased to 40 mg once daily. The antihypertensive effect appears within 2 weeks after starting treatment, with maximum effect generally observed after about 8 weeks. If blood pressure is not controlled with monotherapy, it may be combined with thiazide diuretics such as hydrochlorothiazide. To improve adherence, it is recommended to take the medication at the same time each day (e.g., in the morning). For patients with potential intravascular volume depletion (e.g., patients on diuretics, especially those with renal impairment), it is recommended to start treatment at a low dose while monitoring their condition carefully. <elderly> For elderly patients aged 65 years and older, dose adjustments are not necessary. Overall, no significant differences in efficacy and safety between elderly patients and younger patients have been observed, although some elderly patients may exhibit more sensitive responses. <renal impairment patients> For patients with mild to moderate renal impairment (creatinine clearance 20-60 mL/min), the maximum administered dose is 20 mg once daily. <hepatic impairment patients> Patients with mild hepatic impairment do not require dose adjustments. The recommended initial dose for patients with moderate hepatic impairment is 10 mg once daily, which can be increased up to a maximum of 20 mg per day. There is no experience using this medication in patients with severe hepatic impairment, and its use is not recommended in such cases. <children> The safety and efficacy in children have not been established.

Child dose

The safety and efficacy in children have not been established.

This medication can cause severe harm or death to the fetus and newborn if taken during the second and third trimesters of pregnancy, so it must be discontinued immediately upon confirmation of pregnancy. Individuals allergic to certain ingredients, those who are pregnant or breastfeeding, patients undergoing kidney dialysis, those with severe liver impairment, patients with bile duct obstruction, and individuals with genetic problems such as lactose intolerance should not take this medication. Patients with reduced blood volume or salt, those with impaired kidney function, renal artery hypertension patients, those at risk of hyperkalemia, and individuals with certain heart conditions should be particularly cautious when taking this medication, and blood pressure or kidney function should be monitored regularly. During the treatment, dizziness may occur, and it is advisable to avoid dangerous activities such as heavy lifting or driving. In clinical trials, this medication has been generally safe, with the most common side effect reported being dizziness; rare side effects include chest pain, swelling, indigestion, headache, and skin rash. If chronic diarrhea or weight loss occurs, it may be necessary to discontinue this medication due to the potential for intestinal disease. Interactions may occur when taken with potassium-sparing diuretics or potassium supplements, certain antihypertensives, lithium, and non-steroidal anti-inflammatory drugs, so consulting a physician is recommended. Due to the severe risk of fetal harm, this medication should be discontinued immediately upon confirmation of pregnancy, and if breastfeeding, consideration should be given to discontinuing either the medication or breastfeeding, as abnormal reactions may occur in infants. The safety and efficacy in children have not been sufficiently established, and elderly patients may have different metabolic capacities, so caution is warranted. In the event of overdose, symptoms such as hypotension or palpitations may occur, and appropriate treatment should be provided if necessary. This medication is known to have a low risk of carcinogenicity or genotoxicity, but if any unusual symptoms appear during use, immediate consultation with healthcare professionals is advised.

Serious side effects

• Hives
• severe swelling (angioedema)
• chest pain
• asthma
• increased blood creatinine
• acute renal failure
• hyperkalemia
• hives
• itching
• anaphylactic reaction

Mild side effects

• Dizziness
• headache
• palpitations
• low back pain
• hematuria
• hyperglycemia
• hypertriglyceridemia
• flu-like symptoms
• pharyngitis
• rhinitis

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. It is preferable to maintain the storage temperature between 1 and 25 degrees Celsius to preserve its effectiveness for a long time.

Appearance

White round film-coated tablet

Package unit

30 tablets/box [(10 tablets/blister x 3)], 30 tablets/bottle, 300 tablets/bottle