Humetec Tablets 20 mg (Olmesartan Medoxomil)

Adult dose

The recommended initial dose for adults is 10 mg once daily, regardless of meals. If blood pressure is not adequately controlled at this dose, it may be increased to 20 mg once daily, with a maximum of 40 mg per day. Blood pressure-lowering effects typically appear within 2 weeks of treatment initiation, with maximum effects occurring around 8 weeks. If blood pressure remains uncontrolled, it may be combined with a thiazide diuretic. For better adherence, it is recommended to take the medication at the same time each day (e.g., in the morning). In patients who may have reduced effective blood volume (e.g., those taking diuretics, especially with kidney impairment), observe carefully and consider starting treatment at a lower dose. <Elderly> No dose adjustment is necessary for patients aged 65 and older. Overall, no significant differences have been observed between elderly and younger patients regarding efficacy and safety, though heightened sensitivity may not be ruled out in some elderly individuals. <Renal impairment patients> For patients with mild to moderate renal impairment (creatinine clearance 20-60 mL/min), the maximum dosage is 20 mg once daily. <Liver impairment patients> Mild liver impairment does not require dose adjustment. For moderate liver impairment, the recommended initial dose is 10 mg once daily, with a maximum increase to 20 mg per day. There is no experience with severe liver impairment, and the use of this medication is not recommended. <Children> Safety and efficacy in children have not been established.

Child dose

The safety and efficacy in children have not been established.

This medication can cause serious harm or even death to the fetus or newborn if taken during the second or third trimester of pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Do not take this medication if you are allergic to any of the ingredients, pregnant or breastfeeding, undergoing renal dialysis, have severe liver disorders, have bile duct obstruction, or have genetic issues such as lactose intolerance. Be cautious if you have low blood volume or salt levels before taking this medication, as low blood pressure may occur; immediate appropriate actions must be taken if low blood pressure develops. Patients with impaired kidney function or those who have received a kidney transplant should regularly check potassium levels and kidney function indicators. Severe renal impairment is not advised for use of this medication. Patients with specific heart diseases or those at risk of hyperkalemia should regularly monitor serum potassium levels while on this medication. This medication may cause dizziness; caution is required when operating hazardous machinery or driving. If gastrointestinal symptoms such as chronic diarrhea or weight loss occur while taking this medication, consult a physician immediately. If symptoms of intestinal vascular edema appear, discontinue use and seek appropriate treatment. Caution is advised when taken with potassium-sparing diuretics or potassium supplements as it may dangerously elevate blood potassium levels, as well as with lithium or non-steroidal anti-inflammatory drugs. Taking this medication during pregnancy may lead to serious adverse effects in the fetus, such as low blood pressure, renal function impairment, and skull development issues; thus, it should be discontinued immediately upon confirmation of pregnancy. Breastfeeding may allow this medication to pass into breast milk, potentially causing adverse reactions in infants; therefore, it is recommended to either discontinue breastfeeding or stop taking the medication. The safety and efficacy of this medication in children have not been sufficiently established, so it should be administered cautiously to children. In elderly patients, the concentration of this medication may increase in the body, requiring caution during use. Overdosage may result in symptoms such as low blood pressure and palpitations, and appropriate treatment should be received if necessary. It has been reported that the risk of carcinogenicity or genotoxicity is low even with long-term administration of this medication; however, any adverse reactions should be reported to a healthcare professional immediately.

Serious side effects

Urticaria, angioedema, anaphylaxis, intestinal vascular edema, rhabdomyolysis, hyperkalemia, acute renal failure, elevated serum creatinine, abnormal liver function tests (increased transaminases or total bilirubin), autoimmune hepatitis, asthma

Mild side effects

• Dizziness
• headache
• palpitations
• back pain
• bronchitis
• increased creatine phosphokinase
• diarrhea
• hematuria
• hyperglycemia
• hypertriglyceridemia

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 degree to 25 degrees Celsius. Proper storage facilitates the maintenance of the medication's effectiveness and prevents deterioration.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle