Kobartane Tablet 80/12.5 mg (Valsartan, Hydrochlorothiazide)

Adult dose

The recommended adult dosage is 1 tablet daily of valsartan 80 mg/hydrochlorothiazide 12.5 mg, taken with a small amount of water regardless of meals. Valsartan 160 mg/hydrochlorothiazide 12.5 mg is applied if prescribed for blood pressure reduction. No dosage adjustment is required for patients with mild to moderate renal impairment (creatinine clearance 30 mL/min or more).

This medication can cause serious harm to the fetus if taken during pregnancy, especially in the second and third trimesters. Therefore, it should be discontinued immediately upon confirmation of pregnancy. Individuals with allergies to the ingredients of this medication or sulfonamide drugs, as well as pregnant or potentially pregnant women, should not take this medication. Patients with severely impaired liver or kidney function, as well as those with specific liver or kidney diseases, should not take this medication. This medication lowers blood pressure, so patients with hypotension or electrolyte abnormalities, and those with heart or cerebrovascular diseases should use caution when taking it. In particular, elderly patients, diabetic patients, lupus patients, and heart failure patients should frequently check renal function and electrolyte status while taking this medication. The hydrochlorothiazide component may increase sensitivity to sunlight and the risk of skin cancer, so exposure to sunlight should be avoided and skin condition should be closely monitored. Dizziness or drowsiness may occur when taking this medication, so caution is needed when driving or operating machinery. Potassium supplements or potassium-containing medications should not be taken without discussing with a doctor, and blood potassium levels should be regularly monitored. There may be interactions with other medications, so especially those taking lithium, non-steroidal anti-inflammatory drugs (NSAIDs), and other antihypertensive medications should certainly consult with a physician. This medication has not been shown to be safe and effective in children, so it is best not to use it. Overdose may present with hypotension, arrhythmia, electrolyte abnormalities, etc., and if symptoms occur, immediate medical attention should be sought. This medication should be stored away from moisture and direct sunlight, and kept out of reach of children.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, angioedema, anaphylactic reactions, severe allergic reactions, severe rash with high fever, blistering, skin peeling, oral/ocular mucosal pain, toxic epidermal necrolysis (Lyell syndrome), hepatitis, skin adverse reactions, liver abnormalities (jaundice), pulmonary edema, renal failure, dyspnea, interstitial pneumonia, pulmonary edema, hyponatremia (accompanied by consciousness disturbance), shock, syncope, loss of consciousness

Mild side effects

• Headache
• dizziness
• rhinitis
• fatigue
• low back pain
• cough
• upper respiratory infection
• diarrhea
• arthralgia
• abdominal pain

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it should be maintained in a cool place at or below 30 degrees Celsius for optimal effectiveness.

Appearance

Bright orange oval film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle