Simvastatin/Ezetimibe Tablet 10/20

Adult dose

This medication is administered once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia, the dosage range is 10/10mg to 10/40mg daily, with the generally recommended starting dose being 10/20mg daily. Patients with a lower need for LDL cholesterol reduction may start with 10/10mg daily. After initiating this medication or adjusting the dose, blood lipid levels should be checked at intervals of at least 4 weeks to adjust the dosage.

This medication can cause serious muscle-related side effects, such as myopathy and rhabdomyolysis. Particularly when taken at high doses or in combination with certain medications, these risks may increase, so caution is advised. If symptoms such as muscle pain or weakness occur, notify a doctor immediately and discontinue use if necessary. This medication should not be used in patients with hypersensitivity to any component, in patients with active liver disease, or in pregnant or nursing women. Additionally, patients taking certain antifungal agents, antibiotics, immunosuppressants, etc., should not take this medication. Patients with lactose intolerance should also avoid this medication. Patients with severe myasthenia gravis or ocular myasthenia gravis should take this medication cautiously and discontinue if symptoms worsen. Patients with poor liver function should undergo liver function tests before taking this medication and monitor liver function regularly during treatment. This medication may cause side effects such as headache, indigestion, diarrhea, cold symptoms, muscle pain, limb pain, weakness, abdominal pain, constipation, nausea, itching, rash, fatigue, dizziness, insomnia, sore throat, hematuria, nocturia, and weight loss in some patients. Especially in elderly patients or those with decreased kidney function, the risk of side effects is higher, so caution is required. This medication may interact with several other drugs, so inform your doctor or pharmacist if you are taking any other medications. Women who are pregnant or may become pregnant should not take this medication and should discontinue use immediately if pregnancy is confirmed during treatment. Nursing women should also discontinue breastfeeding if taking this medication. Safety in children and adolescents has not been sufficiently established, so consult a specialist if necessary before administration. In the case of an overdose, there is no specific antidote, so general treatment and supportive care will be provided. This medication helps reduce cardiovascular disease risk but must be used in accordance with the above precautions.

Serious side effects

• Hives
• severe swelling (edema)
• chest tightness
• difficulty breathing
• cold sweat
• pallor
• angioedema
• rash
• pancreatitis
• cholelithiasis

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory infection
• muscle pain
• limb pain
• weakness
• abdominal pain
• constipation
• indigestion

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

White to off-white, bilaterally convex, rectangular tablet

Package unit

30 tablets (10 tablets/PTP × 3)