Simba-comib Tablet 10/20mg

Adult dose

This medication is administered once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia, the daily dosage ranges from 10/10mg to 10/40mg, with the generally recommended starting dose being 10/20mg once daily. Patients with less need for LDL cholesterol reduction may start with 10/10mg once daily. After initiation or adjustment of dosage, blood lipid levels should be checked at intervals of more than 4 weeks.

This medication is primarily used to lower blood cholesterol levels. Muscle pain or weakness may occur during treatment, and rarely, a serious condition called rhabdomyolysis can develop, resulting in severe muscle damage. The risk can be heightened, especially when taken in high doses or in conjunction with specific medications. Patients with liver function issues or elevated liver enzyme levels should not take this medication, and regular testing is necessary if liver dysfunction is suspected. Women who are pregnant or nursing should not take this medication, and women of childbearing age must confirm pregnancy status before use. This medication can lead to higher blood concentrations when taken with drugs that inhibit certain enzymes (CYP3A4), thus increasing the risk of side effects. Therefore, patients should consult a physician if they are under treatment with such drugs. Additionally, interactions with certain anticoagulants, specific antibiotics, and calcium channel blockers exist; patients taking other medications should notify their healthcare providers. If unexplained muscle pain, muscle weakness, changes in urine color, or other adverse symptoms occur, patients should immediately notify a physician and discontinue treatment. This medication should also be used cautiously in elderly patients or those with reduced kidney function, and regular blood tests to monitor liver and muscle condition are advisable. In cases of overdose, there is no specific antidote, and immediate medical attention is necessary for appropriate treatment. Finally, it is advisable to limit the intake of certain foods, such as grapefruit juice, while taking this medication and to inform other healthcare providers about its use.

Serious side effects

Hives, severe swelling (edema), angioedema, chest tightness, difficulty breathing, respiratory distress, toxic epidermal necrolysis (Lyell syndrome), skin mucosal syndrome (Stevens-Johnson syndrome), severe allergic reactions, severe skin adverse reactions, blood vessel swelling, rash, pancreatitis, hepatitis, cholestatic jaundice, fulminant hepatic necrosis, liver cancer, hepatic failure, skin and mucosal issues, alopecia, liver dysfunction (jaundice), headache, confusion, vision

Mild side effects

Headache, diarrhea, influenza, upper respiratory infection, muscle pain, limb pain, fatigue, nausea, abdominal pain, constipation, indigestion, flatulence, vomiting, itching, alopecia, increased creatine phosphokinase (CPK) in the blood, weight loss, weakness, sensory loss, nocturia, hematuria, insomnia, gastritis, atrophic gastritis, mucoid stools, irritable bowel syndrome, sore throat, cataracts, gynecomastia, decreased libido, sexual dysfunction, anemia, HbA1c and public

This medication is sensitive to air and moisture, so it should be stored in a sealed container. The recommended storage temperature is between 1 to 30 degrees Celsius at room temperature.

Appearance

White to whitish convex rectangular tablets on both sides

Package unit

30 tablets (10 tablets/Alu-Alu*3)