Simbacomib Tablets 10/10mg

Adult dose

This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is from 10/10mg to 10/40mg per day, and the generally recommended initial dose is 10/20mg per day. Patients who require less reduction in LDL-cholesterol can start with 10/10mg per day. For patients with homozygous familial hypercholesterolemia, the recommended dose is 10/40mg per day taken once in the evening.

This medication is used to lower blood cholesterol levels to reduce the risk of cardiovascular disease. However, it carries a risk of muscle problems, so any symptoms of muscle pain or weakness should be promptly reported to a healthcare professional. Especially when taken at high doses, the risk of muscle damage, such as myopathy or rhabdomyolysis, may increase. Patients with an allergy to any component of this medication, severe liver impairment, or women who are pregnant or breastfeeding should not take this medication. Additionally, co-administration with certain antifungals, antibiotics, antiviral medications, and other drugs that inhibit the metabolism of this medication in the liver may increase the risk of muscle damage, so such combinations should be avoided. This medication contains lactose, thus patients with lactose intolerance are also advised against taking it. Elderly patients, those with hypothyroidism, and patients with reduced kidney function should take extra precautions when using this medication. Those with liver dysfunction should undergo regular liver function tests, and discontinuation is required if liver enzyme levels rise significantly. During treatment, it is important to inform other physicians about the use of this medication and to consult with a physician before starting any new medications. Women planning to become pregnant should not take this medication, and it should be stopped immediately if pregnancy occurs during use. This medication may raise blood sugar levels in some patients, so thorough blood sugar management is essential for patients at risk of diabetes. In case of overdose, there are no specific antidotes, and symptomatic treatment will be provided. Consumption of grapefruit juice in large quantities may increase the blood concentration of this medication and raise the risk of side effects, so grapefruit juice should be avoided. During treatment, side effects such as muscle pain, fatigue, dyspepsia, and headache may occur, and if symptoms worsen, consultation with a healthcare professional is recommended.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash accompanied by high fever, blisters, skin peeling, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attack, respiratory distress accompanied by cough and fever, yellowing of the skin or eyes (jaundice), profound lethargy, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual disturbances, paralysis, urinary retention

Mild side effects

Headache, diarrhea, influenza, upper respiratory infection, muscle pain, limb pain, fatigue, nausea, abdominal pain, constipation, upper abdominal pain, vomiting, itching, nocturia, hematuria, insomnia, gastritis, atrophic gastritis, dyspepsia, mucus stool, irritable bowel syndrome, sore throat, alopecia, gynecomastia, decreased libido, sexual dysfunction (including erectile dysfunction), progression of cataracts, ocular muscle paralysis, anemia, weight loss, sensory disturbances, dizziness, fainting, cough

This medication is sensitive to air and moisture, thus the bottle should be tightly closed during storage. Additionally, it is advised to avoid extremely hot or cold places and store between 1°C and 30°C at room temperature.

Appearance

A white to light yellow, biconvex, rectangular tablet

Package unit

30 tablets (10 tablets/Alu-Alu*3)