Easy Simvastatin Tablets 10/10 mg (Ezetimibe, Simvastatin)

Adult dose

This drug is taken once daily in the evening, with or without meals. For patients with primary hypercholesterolemia, the recommended dosage is between 10/10 mg and 10/40 mg daily, generally starting with a dose of 10/20 mg once daily. Patients who require less reduction in LDL cholesterol may start at 10/10 mg once daily. For patients with homozygous familial hypercholesterolemia, the recommended dose is 10/40 mg once daily in the evening.

This drug is used to lower blood cholesterol levels. While taking this drug, symptoms such as muscle pain or weakness may occur, which can lead to serious side effects such as myopathy or rhabdomyolysis. Particularly, the risk may increase when taking high doses or in combination with certain other medications, so caution is needed. Patients with impaired liver function or liver disease should not use this drug as it can worsen liver function. Women who are pregnant or nursing should not take this drug, and women who may become pregnant must consult a doctor before use. Taking this drug together with medications that inhibit certain enzymes can increase blood levels and the risk of side effects, so it is essential to inform if there are any co-administered medications. Particularly, the risk of muscle-related side effects may increase when used with antifungals, antibiotics, some cardiac medications, immunosuppressants, and fibrates. If muscle pain, muscle weakness, or unexplained muscle symptoms occur during treatment, inform a doctor immediately and discontinue the drug if necessary. Additionally, regular liver function tests and muscle enzyme tests are recommended. This drug should be used cautiously in children, especially in those under 10 years old, as safety and efficacy have not been fully established. Elderly patients may also be more sensitive to this drug, so careful monitoring is needed. Certain foods like grapefruit juice should be avoided while taking this drug, and it is important to inform healthcare providers when starting any new medications while on this drug.

Serious side effects

Hives, angioedema, rash, anaphylaxis, myopathy, rhabdomyolysis, hepatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), polymorphic erythema, severe skin reactions, liver abnormalities (including jaundice), severe edema, severe allergic reactions, severe muscle weakness, ocular muscle weakness, kidney damage, fatal liver failure, acute renal failure, interstitial lung disease, severe rash, blisters, skin.

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory tract infection
• muscle pain
• limb pain
• fatigue
• abdominal pain
• nausea
• constipation

This drug should be stored in a sealed container as it is sensitive to air and moisture. It is recommended to keep it at room temperature between 1 to 30 degrees Celsius.

Appearance

White to light yellow, bi-convex, rectangular tablets

Package unit

30 tablets (10 tablets/Alu-Alu x 3)