Duo Difin Tablet

Adult dose

This medication should be administered only to adults, and the dosage should be individualized based on the efficacy and tolerability of amlodipine/atorvastatin in each patient. Amlodipine (esamlodipine) is taken orally once daily at a dose of 5(2.5) mg and may be increased to a maximum of 10(5) mg daily based on the patient's response. The recommended initial dose of atorvastatin is 10 mg once daily for adults.

This medication should not be used in certain patients. For instance, patients who are allergic to this medication or similar ingredients, those with severe liver problems, pregnant women or women who may become pregnant, nursing women, patients with severe muscle diseases, patients with severely narrowed heart valves, patients in shock, patients within one month after a myocardial infarction, and patients with unstable angina should not take this medication. Additionally, patients with severely impaired kidney function, elderly individuals, patients with a history of alcoholism or liver disease, and those at risk of muscle damage should use this medication cautiously. Since this medication poses a risk of muscle abnormalities, patients should consult a doctor immediately if muscle pain or weakness occurs. Side effects such as fatigue, swelling, dizziness, headache, indigestion, muscle pain may occur during the use of this medication, and in rare cases liver dysfunction or allergic reactions may also occur. Therefore, regular liver function tests should be conducted, and any unusual symptoms should be reported to healthcare professionals immediately. This medication may interact with other drugs, so patients should inform their doctor or pharmacist about any medications they are currently taking. Care should be taken especially when used concurrently with certain antibiotics, antifungals, immunosuppressants, and specific antiviral drugs. Pregnant women or those planning to become pregnant should consult a doctor before taking this medication, and if pregnancy is confirmed during treatment, they should stop taking it immediately and inform healthcare professionals. Nursing women are also advised to avoid taking this medication. The safety and effectiveness of this medication in children and the elderly have not been adequately established; thus, consultation with healthcare professionals is required prior to use. In case of overdose, blood pressure may drop excessively and cardiac rhythm abnormalities may occur, so patients should immediately visit a medical institution for appropriate treatment. Lastly, this medication should be stored out of reach of children and should not be transferred to another container for safety.

Serious side effects

Hives, severe swelling (edema), severe allergic reactions, toxic epidermal necrolysis, angioedema, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, severe skin reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory issues accompanied by cough + fever, respiratory problems, jaundice (yellowing of skin or eyes), profound fatigue, liver abnormalities (jaundice), sudden and severe headache,

Mild side effects

• Flushing
• fatigue
• swelling
• palpitations
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• weakness

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is recommended to keep it in a cool place between 15 to 30 degrees Celsius. This way, the efficacy of the medication can be maintained for a long time.

Appearance

White oval film-coated tablets

Package unit

30 tablets per bottle