Innozen Abeltan Plus Tablet 300/12.5 mg

Adult dose

This medication is to be taken once daily, regardless of meals. 1. For patients whose blood pressure is not sufficiently controlled with monotherapy, it can be administered as follows: - Irbesartan 150 mg/Hydrochlorothiazide 12.5 mg once daily, 1 tablet - Irbesartan 300 mg/Hydrochlorothiazide 12.5 mg once daily, 1 tablet - Irbesartan 300 mg/Hydrochlorothiazide 25 mg once daily, 1 tablet Doses exceeding Irbesartan 300 mg/Hydrochlorothiazide 25 mg are not recommended. If needed, this medication can be combined with other antihypertensive agents. 2. When treating moderate or severe hypertension (stage 2) with this medication as initial therapy, it should be individualized based on baseline blood pressure, treatment goals, and the expected increase in the likelihood of achieving treatment goals compared to monotherapy. Typically, this is started as Irbesartan 150 mg/Hydrochlorothiazide 12.5 mg once daily, and if blood pressure control is needed, the dose may be increased to a maximum of Irbesartan 300 mg/Hydrochlorothiazide 25 mg after 1 to 2 weeks. This medication is not recommended as initial therapy in patients with intravascular volume depletion. ○ Patients with kidney impairment Due to the hydrochlorothiazide component, this medication is not recommended for patients with severe renal impairment (creatinine clearance < 30 mL/min). Loop diuretics are preferred in these patient populations. No dose adjustment is needed for patients with creatinine clearance above 30 mL/min. ○ Patients with volume depletion In cases of sodium and/or fluid loss, equilibrium must be restored before administering this medication. ○ Patients with liver impairment This medication is not used in patients with severe liver impairment. Thiazide medications should be used with caution in patients with liver impairment. No dose adjustment is needed for patients with mild to moderate liver impairment. ○ Elderly patients No dose adjustment is needed for elderly patients. ○ Pediatric patients The safety and efficacy of this medication have not been established in pediatric patients and adolescents under 18 years of age.

Child dose

The safety and efficacy of this medication have not been established in pediatric patients and adolescents under 18 years of age.

This medication can cause serious harm to the fetus and newborn, especially during the second and third trimesters of pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Women who are pregnant, potentially pregnant, or nursing should not take this medication. Additionally, patients with a known allergy to this drug or its components, severe renal impairment, anuria, or certain liver diseases should avoid using this medication. Caution is advised in patients with specific conditions such as hypotension, kidney issues, liver disorders, heart valve disease, or angle-closure glaucoma. The hydrochlorothiazide component may increase the risk of skin cancer due to sensitivity to sunlight, so exposure to ultraviolet light should be limited, and skin changes should be closely monitored during use. Various side effects such as dizziness, fatigue, nausea, and abnormal urination may occur; if symptoms are severe or persistent, consult a physician. Hypotensive symptoms may arise during hypertension treatment, so it is important to prevent and manage dehydration or sodium deficiency. Regularly check kidney function and electrolyte levels via blood tests, particularly potassium levels, as they can pose health risks if too high or too low. Be sure to inform a doctor or pharmacist of any other medications being taken as there may be interactions. Diabetic patients may be affected by blood sugar control, so blood sugar levels and treatment plans should be regularly monitored. This medication is not recommended for children or adolescents as safety and efficacy have not been established. Older patients may be more sensitive to this medication and should be monitored more closely during use. In case of overdose, symptoms such as hypotension, electrolyte imbalance, and dehydration may occur, so contact a healthcare facility immediately for appropriate treatment. Store this medication out of reach of children and keep it in its original container to maintain quality.

Serious side effects

• Urticaria, severe swelling (edema), angioedema → severe allergic reactions
• Severe rash with high fever, blisters, skin peeling, mouth/eye mucosal pain → severe skin reactions
• Difficulty breathing or dyspnea (including pneumonia and pulmonary edema), asthma attacks, cough with fever → respiratory issues
• Jaundice (yellowing of the skin or eyes) → liver abnormalities (jaundice)
• Sudden and severe headache,

Mild side effects

• Dizziness
• fatigue
• nausea/vomiting
• abnormal urination
• elevated BUN
• increased creatine kinase
• increased creatinine
• headache
• syncope
• hypotension

This medication should be stored in a tightly closed container to protect it from air and moisture, and the storage temperature should be kept between 1°C and 30°C. Proper storage can help maintain the medication's effectiveness for a longer period.

Appearance

Pink, biconvex, oval film-coated tablets

Package unit

30 tablets/bottle