Lisemax Tablet 150 mg (Lisedronic Acid Sodium 2.5 Hydrate)

Adult dose

As Lisedronic acid sodium, administer 150 mg orally once a month. Food can interfere with the absorption of this drug, so it should be taken at least 30 minutes before consuming food or beverages other than water for optimal absorption. This drug should be taken with an adequate amount of pure water (170 to 230 mL) while in an upright position. Do not chew or suck on the tablet, and do not lie down for at least 30 minutes after ingestion.

Child dose

The safety and efficacy in patients under 18 years of age have not been established.

This drug is an oral bisphosphonate, primarily used for the treatment of osteoporosis. It may irritate the upper gastrointestinal mucosa upon administration; therefore, patients with upper gastrointestinal diseases such as Barrett's esophagus, dysphagia, esophageal diseases, gastritis, duodenitis, and ulcers should exercise caution. It is essential to follow the dosage instructions strictly, and after taking the medication, do not lie down for at least 30 minutes, and take it with a sufficient amount of water to reduce the risk of esophageal irritation. If symptoms such as esophagitis, esophageal ulcers, or esophageal erosion appear, immediately stop taking the medication and consult a physician. This drug should not be administered to specific patients, including those with esophageal motility disorders, hypocalcemia, pregnant or nursing women, and those with severe renal impairment. Additionally, patients with genetic issues such as lactose intolerance should not take this drug due to lactose content. It is vital to take sufficient calcium and vitamin D during treatment, and if hypocalcemia or parathyroid dysfunction is present, treatment must occur before use. Similar to other drugs in the same class, rare serious side effects such as osteonecrosis of the jaw, atypical femoral fractures, and osteonecrosis of the external auditory canal have been reported; therefore, if such symptoms occur, immediate consultation with healthcare personnel is necessary. Antacids containing drugs such as calcium, magnesium, iron, and aluminum should not be taken simultaneously as they may interfere with absorption; therefore, the timing of these medications must be adjusted. Pregnant women or women who may become pregnant and nursing mothers should not use this drug, as it may affect the fetus during pregnancy, requiring caution. The safety and efficacy in children have not been established, and the elderly can use it without significant differences, but careful observation is necessary. In case of overdose, symptoms of hypocalcemia may appear, requiring appropriate treatment such as administering ionized calcium, and gastric lavage should be considered. Keep this medication out of reach of children, and avoid transferring it to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of the mouth/eyes, jaundice (yellowing of skin or eyes), extreme lethargy, severe allergic reactions, severe skin reactions, respiratory problems, liver dysfunction (jaundice), sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis,

Mild side effects

• Nausea
• diarrhea
• abdominal pain
• headache
• weakness
• chest pain
• hypertension
• constipation
• dyspepsia
• peripheral edema

This drug should be stored in a tightly sealed container to avoid exposure to air, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. This storage method helps maintain the drug's effectiveness for a longer time.

Appearance

Blue oval film-coated tablet

Package unit

1 tablet (1 tablet/PTPX1)