Cairofin Tablet (Esamlodipine Besylate 2.5 Hydrate)

Adult dose

This medication should be taken with a sufficient amount of water. As esamlodipine, take 2.5 mg orally once daily, and the dose may be increased to a maximum of 5 mg per day based on patient response. Adjust dosage appropriately according to symptoms.

This medication should not be used in patients who have had allergic reactions to this medication, its components, or similar classes of drugs. It is also recommended not to administer to women who are pregnant, may become pregnant, or are breastfeeding. Administration should be avoided in patients in shock states including cardiogenic shock, severe aortic stenosis, unstable angina, and those within 1 month after a myocardial infarction. This medication should not be used in patients with severely impaired liver function and severely low blood pressure. Careful administration is required in patients with severe renal impairment, elderly patients, patients with acute heart failure, hypertensive crisis, and patients with mild to moderate liver dysfunction. Side effects may include facial flushing and feverish sensation, fatigue, swelling of hands and feet, palpitations, dizziness, headache, nausea, drowsiness, and ankle swelling. In rare cases, dry mouth, increased sweating, hypotension, fainting, insomnia, skin rash, and liver dysfunction may occur, and if any unusual symptoms appear, immediate consultation with a doctor is necessary. This medication may worsen symptoms if suddenly discontinued; therefore, the dosage should be gradually reduced under the guidance of a physician, and patients should take care not to stop it arbitrarily. Patients with poor liver function may have higher drug concentrations, which require careful dosage adjustment and monitoring. This medication lowers blood pressure gradually, so it is not suitable for urgent lowering of blood pressure. Take with sufficient water, and avoid driving or operating dangerous machinery if dizziness or drowsiness occur. This medication may interact with many other drugs, so if taking other medications, it is essential to inform healthcare providers, especially caution should be taken to avoid taking it with grapefruit juice. In cases of overdose, severe hypotension, cardiac arrhythmia, and shock may occur, requiring immediate visit to a medical facility for appropriate treatment. Keep out of reach of children and do not transfer medications to other containers for safety. The safety of this medication during pregnancy and breastfeeding has not been established, so it should be avoided in these cases, and its effectiveness has not been confirmed in children under 6 years. Elderly patients may have higher drug concentrations, so treatment should start with a low dose and be administered cautiously.

Serious side effects

• Urticaria, angioedema → severe allergic reactions
• Hepatitis, jaundice, elevated liver enzymes, clinical symptoms of liver dysfunction (weakness, anorexia, prolonged nausea) → liver abnormalities (jaundice)
• Paralysis → serious neurological symptoms
• Difficulty breathing, dyspnea → respiratory problems
• Severe edema, systemic edema associated with high blood pressure
• Severe rash, blisters, skin peeling, pain in mucous membranes of mouth/eyes → severe skin abnormal reactions
• Severe headache → serious

Mild side effects

• Flushing with warmth
• fatigue
• swelling
• palpitations
• dizziness
• headache
• migraine
• weakness
• abdominal pain
• nausea

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1 to 30 degrees Celsius at room temperature. This storage method helps maintain the effectiveness of the medication for a longer period.

Appearance

Pale yellow heart-shaped tablet with a scored line

Package unit

30 tablets/bottle, 300 tablets/bottle