Medication info

Neocap Liquid (Caffeine Citrate)

Prescription medicationSolution
Ingredient · strength
Anhydrous Caffeine›10mg / 1mLCitric Acid Hydrate›5mg / 1mLSodium Citrate Hydrate›8.3mg / 1mL
Manufacturer / importer
(주)한국팜비오
Appearance
A colorless and transparent liquid in a colorless and transparent vial
Packaging
10 vials/box [(1mL/vial x 10)], 10 vials/box [(2mL/vial x 10)]
Approval status
Active

MFDS item code 201003573 · Approved 2010.05.18 · Insurance code 659900450,659900540

Summary

Main use
Improvement of apnea in premature infants
Who uses it
Adults
Adult dosage
Initial Dose: Administer 1mL/kg intravenously for over 30 minutes using a syringe pump. Maintenance Dose: Administer 0.25mL/kg orally or intravenously for over 10 minutes once daily.

Ingredients

Manufacturer
(주)한국팜비오

Efficacy & effects

Improvement of apnea in premature infants

  • Apnea in premature infants
View approved original text

Apnea in premature infants refers to irregular or halted breathing shortly after birth. In this case, it is important to stabilize breathing and ensure adequate oxygen supply through appropriate treatment. Pharmaceutical treatment helps alleviate apnea symptoms and improve respiratory function. Medications that primarily stimulate the central nervous system or strengthen respiratory muscles are used. Such treatments protect the health of premature infants and support normal growth and development. Therefore, it is actively used for the treatment of apnea in premature infants.

Dosage and Administration

Adult dosage

Initial Dose: Administer 1mL/kg intravenously for over 30 minutes using a syringe pump. Maintenance Dose: Administer 0.25mL/kg orally or intravenously for over 10 minutes once daily.

Precautions

This drug can cause a serious intestinal disease called necrotizing enterocolitis when administered to newborns, so the condition of the newborn should be closely monitored during treatment. Someone with an allergy to the ingredients in this drug should never use it. Patients with seizures or problems with the heart, liver, or kidneys should use this drug cautiously and consult with healthcare professionals as necessary. This drug can cause various side effects, such as skin rash, gastrointestinal issues, heart rhythm abnormalities, and neurological disturbances, so any abnormal symptoms should be reported to healthcare professionals immediately. Particularly, blood glucose levels in newborns should be checked periodically, and it is important to first confirm that there are no other causes for apnea during treatment. This drug stimulates the central nervous system, so an overdose may lead to seizures and can increase heart rate and blood flow, necessitating caution in patients with heart disorders. Patients with weak liver or kidney function should frequently monitor the drug concentration in the blood to maintain an appropriate dosage. As this drug may interact with other drugs, especially certain antibiotics or medications that affect liver metabolism, it is crucial to consult with healthcare professionals before co-administering. The safety of this drug in pregnant women has not been sufficiently confirmed, so pregnant women must consult with experts before use. In the case of an overdose, symptoms such as fever, tremors, vomiting, and seizures may occur, requiring immediate emergency treatment. This drug is for single use only, and any remaining amount must be discarded. Before administration, it should be ensured that there is no discoloration or foreign substances. During storage, it should be kept out of reach of children and maintained at a temperature between 15-30 degrees Celsius to preserve the effectiveness of the drug.

Side effects and when to seek care immediately

Serious side effects

  • Necrotizing enterocolitis
  • death
  • bleeding
  • disseminated intravascular coagulation
  • intracranial hemorrhage
  • respiratory distress
  • pulmonary edema
  • kidney failure
  • seizures.

Mild side effects

Dry skin, rash, skin breakdown, accidental injury, feeding refusal, sepsis, gastritis, gastrointestinal bleeding, acidosis, abnormal healing, retinopathy of prematurity, central nervous system excitement, tachycardia, increased left ventricular ejection fraction, increased cardiac output, increased gastric aspiration, gastrointestinal intolerance, hypoglycemia, hyperglycemia, increased urine output, increased creatinine clearance, increased sodium and calcium excretion, fever, rapid breathing, tremors, excessive muscle tension, and opisthotonos.

Not everyone experiences these, and they can vary from person to person.

Storage

This drug should be stored in a sealed container to prevent air or moisture from entering. It is advisable to maintain storage temperature between 15 and 30 degrees Celsius. This way, the drug's effectiveness can be safely preserved.

Appearance and packaging

Appearance

A colorless and transparent liquid in a colorless and transparent vial

Package unit

10 vials/box [(1mL/vial x 10)], 10 vials/box [(2mL/vial x 10)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.