Epiduo Gel 0.1%/2.5% (Adapalene/Benzoyl Peroxide)

Adult dosage

Clean and dry the affected area, then apply a thin layer to the entire area with acne once daily in the evening. When applying, use the fingertips to avoid the eyes and lips. If skin irritation occurs, use a non-irritating moisturizer, reduce the frequency of application (e.g., every other day), or temporarily or permanently discontinue treatment. The duration of treatment is determined based on the physician’s diagnosis and initial clinical improvement is usually observed 1 to 4 weeks after starting treatment.

It is advisable not to use this medication until the skin has fully recovered from sunburn. Individuals allergic to this medication or its ingredients should not use it. It is safe to avoid using this medication on injured or damaged skin, areas of sunburn, eczema, or seborrheic dermatitis, as well as severe acne areas. Women who are pregnant or may become pregnant are advised not to use this medication. This medication contains an ingredient called propylene glycol, and individuals allergic to this ingredient should use it with caution. Individuals frequently exposed to sunlight or with photosensitive skin may experience skin irritation when using this product, so caution is advised. Symptoms such as skin dryness, irritation, burning sensation, redness, peeling may occur in the area where this medication is applied, typically most severe within the first week but gradually improving over time. Increasing the dosage will not speed up effectiveness and may worsen skin irritation, so it is important to use only the prescribed amount. If hypersensitivity reactions occur, use should be discontinued immediately. Caution should be exercised to avoid excessive exposure to sunlight or ultraviolet rays, and if unavoidable, it is recommended to apply sunscreen and wear protective clothing. Care should be taken as this medication may bleach hair or dyed clothing upon contact. Co-application with other retinoids or strongly irritating cosmetics should be avoided to prevent increased skin irritation. This medication should not be used during pregnancy, and if pregnancy is confirmed, use should be discontinued immediately. Breastfeeding individuals are advised against using this medication, especially on the breast area. This medication has not been evaluated for safety and effectiveness in children under 9 years of age, so its use is not recommended. This product is a topical application and special care should be taken to prevent contact with mucous membranes such as the eyes, nose, and mouth. In case of contact with eyes, rinse thoroughly with clean water and consult a physician or pharmacist if irritation persists. Keep out of reach of children, and it is advisable not to transfer to another container. If accidentally ingested, seek appropriate medical treatment immediately.

Serious side effects

• Hives
• angioedema
• anaphylactic reaction
• throat tightness
• difficulty breathing
• blisters

Mild side effects

• Dryness of the application site
• irritant contact dermatitis
• burning sensation
• skin irritation sensation
• redness
• skin peeling
• itching
• sunburn
• hypopigmentation
• hyperpigmentation

This medication is sensitive to light, so it should be stored in a container that does not allow light to pass through. Additionally, it is recommended to store it in a cool place below 25 degrees to maintain its efficacy.

Appearance

Opaque gel, white to light yellow

Package unit

15 grams/bottle, 30 grams/bottle