HyalurMate (Sodium Hyaluronate)

Adult administration

Generally, 1 unit should be administered once a week for 3 consecutive weeks into the knee joint or shoulder joint, but the frequency of administration should be adjusted according to symptoms. This medication is administered intra-articularly, so strict aseptic technique must be followed.

This medication should not be used in patients who have had allergic reactions to its components. Caution should also be exercised in patients who have had allergic reactions to other medications, liver dysfunction, or a history of liver disease. Care should be taken if there are skin diseases or infections at the site of injection. Severe allergic reactions such as shock may occur during use, and if symptoms arise, administration should be stopped immediately and appropriate treatment sought. Hypersensitivity reactions such as swelling, redness, or itching in the facial region may occur, and if these symptoms develop, the use of the medication should be discontinued and the hospital informed. Transient pain, swelling, redness, and heat may occur at the injection site, and symptoms such as nausea, vomiting, and fever have been rarely reported. In cases of severe arthritis, it is recommended to use this medication after inflammation has subsided, and post-injection care of the injection site may be beneficial. It is important to ensure the injection site is accurately confirmed to prevent the medication from leaking outside the joint. Injections should be performed in a sterile environment, and if ineffective, it should be administered only up to a maximum of 3 times. If there is fluid in the joint, it is preferable to aspirate it if necessary before administration. This medication is not suitable for intravenous injection or for use in the eyes. A needle gauge of 22-23 is recommended. Care should be taken as the medication may precipitate when used with specific disinfectants. Pregnant women or those who may become pregnant should carefully consider the risks and benefits of using this medication, and it is advisable to avoid use while breastfeeding. Safety in pediatric patients has not been established, and it should only be used with caution when necessary. Elderly patients may have diminished physiological function and should be used with greater caution.

Serious side effects

Hives, severe swelling (edema).

Mild side effects

• Facial and eyelid swelling
• facial redness
• rash
• hives
• itching
• pain
• swelling
• hyperemia
• heat sensation
• localized severe pressure sensation

This medication should be stored in a sealed container to prevent contact with air, and kept in a dark place shielded from light. The storage temperature should be maintained between 2 and 8 degrees Celsius, and care should be taken to avoid freezing.

Appearance

A colorless, transparent, and viscous liquid contained in a colorless, transparent prefilled syringe sealed at both ends with rubber stoppers.

Package unit

3 units (2 mL/unit X 3) / carton