Ireborejeong 5 Micrograms (Ramosetron Hydrochloride)

Adult dose

For male patients with diarrhea-predominant irritable bowel syndrome: Administer 5μg of Ramosetron Hydrochloride orally once daily to adult males. Adjust the dosage appropriately based on symptoms, with a minimum daily dose of 2.5μg and a maximum dose of 10μg. For female patients with diarrhea-predominant irritable bowel syndrome: Administer 2.5μg of Ramosetron Hydrochloride orally once daily to adult females. If symptom relief is insufficient at 2.5μg, the dosage can be increased.

This drug should not be used by those who have had an allergic reaction to this drug or any of its components. It should be used with caution in patients taking other serotonergic drugs, and appropriate monitoring is required after consulting with a doctor. While using this drug, side effects such as constipation or hard stools may occur, so if constipation symptoms appear, report to a doctor immediately. In severe cases, serious complications such as bowel obstruction or intestinal perforation may occur, requiring caution. If symptoms such as abdominal pain or blood in stool occur, serious conditions such as ischemic colitis may be suspected; therefore, stop taking the medication immediately and consult a doctor. This drug should be used cautiously by women who are pregnant or may become pregnant, and it is advisable to stop breastfeeding if nursing. Safety in children and infants has not been established, and use is not recommended. Elderly patients may have impaired bodily functions, so their condition should be monitored more carefully while using this drug. This drug can cause injury to the esophageal mucosa, so it is important to carefully extract the packaged medication for administration. If unusual symptoms such as constipation, abdominal pain, or blood in stool occur while taking this medication, consult healthcare professionals immediately for appropriate actions. Additionally, since this drug is metabolized in the liver, caution is necessary when taking it along with drugs that affect liver function. Due to potential drug interactions, the blood concentration of this drug may increase, so if taking other medications, it is essential to inform healthcare professionals. This drug is used for the treatment of diarrhea-predominant irritable bowel syndrome and is not suitable for constipation-predominant patients. Rather than long-term use, it is advisable to determine whether to continue treatment based on the confirmation of symptom improvement. Lastly, rare side effects such as serotonin syndrome may occur while taking this drug, so if changes in mental state or muscle abnormalities appear, consult healthcare professionals immediately.

Serious side effects

Hives, severe swelling (edema), shock, anaphylaxis, chest tightness, difficulty breathing, ischemic colitis, severe constipation, seizure-like episodes, severe allergic reactions, severe edema or urinary abnormalities, liver abnormalities (symptoms related to jaundice have not been reported), serious neurological symptoms (including seizure-like episodes)

Mild side effects

• Constipation
• hard stools
• nausea
• vomiting
• abdominal pain
• upper abdominal pain
• gastritis
• abdominal discomfort
• hemorrhoids
• difficulty in defecation

This drug should be stored in a tightly closed container to avoid exposure to air or moisture. It is advisable to maintain the storage temperature between 1 degree and 30 degrees Celsius at room temperature.

Appearance

Round pale yellow film-coated tablet

Package unit

100 tablets (10 tablets/PTP x 10)/Box