Dimecept Tablets 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. For 4 to 6 weeks, a dose of 5 mg is administered, and after evaluating clinical response, the dose may be increased to 10 mg. When increasing to 10 mg per day, care should be taken regarding gastrointestinal side effects. For underweight female patients aged 85 years or older, the dose should not exceed 5 mg per day.

Child dose

There is no experience regarding usage in pediatric patients.

This drug contains Donepezil Hydrochloride Hydrate as the active ingredient and is used for the treatment of symptoms of Alzheimer's disease. This drug should not be used in patients who have an allergy to Donepezil Hydrochloride, piperidine derivatives, or any component of the medication. Additionally, it should not be taken by pregnant women, women who may become pregnant, or breastfeeding women. Patients with heart-related diseases or conduction disorders should use this drug with caution as it may lower the heart rate or cause arrhythmias. Patients with peptic ulcers or those taking non-steroidal anti-inflammatory drugs should be cautious due to the risk of gastrointestinal bleeding. Patients with asthma or obstructive lung disease should be careful as bronchoconstriction or increased mucus secretion may worsen symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should also use this drug with caution as symptoms may worsen. Serious side effects such as heart problems, gastrointestinal bleeding, liver dysfunction, seizures, movement disorders, respiratory distress, acute pancreatitis, and renal failure may occur during the use of this drug, so you should consult a doctor immediately if any abnormal symptoms arise. Additionally, various side effects such as nausea, vomiting, diarrhea, insomnia, dizziness, headache, fatigue, muscle pain, rash, and pruritus have been reported, so symptoms should be carefully monitored. This drug is not approved for the treatment of other types of dementia or memory disorders other than Alzheimer's disease, and treatment should be conducted under the supervision of an experienced physician. The therapeutic effect should be regularly evaluated, and if there is no effect, discontinuation should be considered. Patients with cardiovascular diseases, especially those with a history of QT interval prolongation or those taking related medications, need heart monitoring. Caution is required as it may affect the ability to drive or operate machinery, and dizziness or muscle cramps may occur during dose increases. This drug is mainly metabolized in the liver, so patients with impaired liver function should also use it with caution. This drug may interact with other medications, so caution is advised when used in conjunction with medications related to CYP3A4 or CYP2D6, muscle relaxants, anticholinergic drugs, heart medications, and anti-inflammatory pain relievers. It is generally recommended that pregnant or breastfeeding women do not take this medication; if absolutely necessary, they should consult a doctor and consider stopping breastfeeding. Safety for pediatric patients has not been established, so it should not be used in this population. In the case of overdose, cholinergic poisoning symptoms such as nausea, vomiting, sweating, bradycardia, hypotension, and respiratory depression may occur, requiring immediate medical treatment. This medication should be stored out of reach of children, and it is safer not to transfer it to another container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, severe rash with fever, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes, feeling short of breath or difficulty breathing, asthma attacks, abnormal breathing accompanied by coughing + fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination

Mild side effects

• Cold
• loss of appetite
• hallucinations
• agitation
• aggressive behavior
• anxiety
• insomnia
• drowsiness
• increased libido
• talking excessively

This medication should be stored in a tightly closed container to prevent air and moisture from entering, and it is safe to keep it at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the drug's effectiveness.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle