Cozaar Plus Tablet

Adult dose

The usual dosage for adults is one tablet of Losartan Potassium 50 mg / Hydrochlorothiazide 12.5 mg once daily. A dose exceeding Losartan Potassium 100 mg / Hydrochlorothiazide 25 mg per day is not advisable. For patients whose blood pressure is not controlled with monotherapy of Losartan or Hydrochlorothiazide, treatment should start with Losartan Potassium 50 mg / Hydrochlorothiazide 12.5 mg once daily.

Child dose

There is no experience with the use in pediatric and adolescent populations (under 18 years), so it is not administered.

This medication may cause severe harm to the fetus and newborn when administered to pregnant women; therefore, it should be discontinued immediately upon confirmation of pregnancy. This medication should not be used in patients with certain conditions, such as anuria, severe liver impairment, severe kidney impairment, or women who are pregnant or may become pregnant. Patients with hypotension or problems with kidney function require special caution when administering this medication, as blood pressure may drop too low, thus their condition should be monitored closely. This medication can affect serum electrolyte levels, so regular blood tests to check levels of sodium, potassium, etc., are necessary. The Hydrochlorothiazide component may increase sensitivity to sunlight, raising the risk of skin cancer; therefore, sun exposure should be limited and protective measures should be taken. Dizziness or drowsiness may occur while taking this medication, so care should be taken when driving or operating machinery. There may be interactions with other medications, so consultation with a doctor or pharmacist is essential when used with potassium supplements, certain diuretics, antihypertensive drugs, etc. This medication may cause adverse reactions in infants when administered to nursing women; thus, it is recommended to either discontinue nursing or stop medication. Safety and efficacy have not been established for pediatric and adolescent patients, so it should not be used in these populations. In elderly patients, adverse reactions may occur more frequently; therefore, caution is advised during use. Overdosing may cause symptoms such as hypotension and bradycardia, in which case immediate medical attention is required. When storing this medication, keep it out of the reach of children and store it tightly closed in its original container.

Serious side effects

• Hives, severe swelling (edema), angioedema (swelling of lips and eyelids and facial swelling), chest tightness, difficulty breathing, laryngeal/glottic swelling due to angioedema, swelling of the face/lips/pharynx/tongue, cold sweat, pallor (severe allergic reaction).
• Severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), exfoliative dermatitis.

Mild side effects

• General: Abdominal pain, weakness/fatigue, diarrhea, nausea, headache, malaise, fever, fainting, lethargy, orthostatic hypotension, facial swelling.
• Cardiovascular: Palpitations, angina, arrhythmias (atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), hypotension, myocardial infarction, secondary AV block.
• Gastrointestinal: Anorexia, constipation, tooth pain, dry mouth, dyspepsia, flatulence, gastritis, vomiting, abdominal pain, gastric irritation, pancreatitis.
• Musculoskeletal: Back pain, arm pain, joint pain.

This medication is sensitive to light and should be stored in a special container that prevents light exposure. Additionally, it should be kept at room temperature between 1 to 30 degrees Celsius. Proper storage will maintain the effectiveness of the drug for a longer time.

Appearance

Yellow oval film-coated tablets inscribed with '717' on one side.

Package unit

30 tablets (15 tablets/PTP x 2 PTP), 300 tablets (300 tablets/bottle)