Silvercept 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. After administering 5 mg for 4 to 6 weeks, clinically evaluate the response to potentially increase to 10 mg. When increasing to 10 mg daily, be cautious of gastrointestinal adverse reactions. Underweight elderly women should not exceed a dosage of 5 mg daily.

Child dose

There is no experience using this medication in pediatric patients.

This drug is a medication with Donepezil Hydrochloride Monohydrate as its main ingredient, used for the treatment of symptoms of Alzheimer's type dementia. First, this medication should not be administered to patients who are hypersensitive to Donepezil Hydrochloride, piperidine derivatives, or any components of this drug, as well as to pregnant or potentially pregnant women and nursing mothers. Patients with heart disease or conduction disorders should use this medication cautiously as it may stimulate the vagus nerve, causing bradycardia or arrhythmias. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be cautious as this medication may exacerbate ulcer symptoms by promoting gastric acid secretion and gastrointestinal motility. Patients with a history of asthma or obstructive pulmonary disease should be careful, as bronchial smooth muscle contraction and increased mucus secretion may worsen symptoms. This medication may excessively stimulate cholinergic nerves in patients with extrapyramidal disorders such as Parkinson's disease, potentially worsening their symptoms. Serious adverse reactions such as syncope, bradycardia, heart block, gastrointestinal bleeding, hepatic dysfunction, cerebrovascular disorders, extrapyramidal symptoms, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and unexplained sudden death may occur during treatment; if such symptoms arise, consult a physician immediately. Additionally, common side effects reported include nausea, vomiting, diarrhea, dizziness, insomnia, headaches, fatigue, appetite decrease, etc. This medication is approved for use only in Alzheimer's type dementia and should not be used for other forms of dementia or memory disorders. Patients with cardiovascular diseases may require monitoring, such as an electrocardiogram, as this medication can affect heart rhythm. Caution is necessary since this medication may influence driving or operating machinery, especially at initial use or during dosage increases. This drug is metabolized by certain enzymes (CYP3A4, CYP2D6), so caution is advised when it is used in conjunction with other drugs that inhibit or induce these enzymes due to possible changes in therapeutic effects and side effect risks; consultation with a professional is recommended. Pregnant or nursing women should generally avoid this drug, and if necessary, it should be used cautiously under professional judgment. Safety has not been established for children, and it should not be administered to pediatric patients. In case of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, and convulsions may appear, requiring immediate emergency treatment, and antidotes such as atropine may be used. Finally, this medication should be stored out of the reach of children, and it is advisable not to transfer it to another container to maintain safety and quality.

Serious side effects

• Syncope
• bradycardia
• heart block
• QT interval prolongation
• myocardial infarction
• heart failure
• peptic ulcers
• perforated duodenal perforation
• gastrointestinal bleeding
• hepatitis

Mild side effects

• Headache
• dizziness
• diarrhea
• nausea
• vomiting
• appetite loss
• fatigue
• tremors
• insomnia
• drowsiness

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. The storage temperature should ideally be maintained between 1 and 30 degrees Celsius. Proper storage will ensure the medication's effectiveness is safely preserved.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle