DuoMax Tablets

Adult dose

This medication is administered solely to adults, and the dosing should be individualized based on the efficacy and tolerance of the components amlodipine/atorvastatin for each patient. Amlodipine (Esamlodipine): Adults should take 5 (2.5) mg orally once daily, and the dose may be increased to a maximum of 10 (5) mg daily depending on the patient’s response. Adjustments should be made according to symptoms. Atorvastatin: For patients with primary hypercholesterolemia and mixed dyslipidemia, the initial recommended dose is 10 mg once daily, but it can be started at 20 mg or 40 mg once daily if greater reductions in LDL cholesterol are required (only when a reduction of over 45% in LDL cholesterol is needed). This medication is administered in a dose range of 10 mg to 80 mg once daily, and it can be taken at any time regardless of meals. The initial and maintenance doses of this drug should be individualized considering treatment goals and responses; lipid levels should be analyzed within 2 to 4 weeks after initiation and/or dose adjustment, and doses should be modified accordingly. For patients with homozygous familial hypercholesterolemia, dosing is 10 mg to 80 mg once daily, in combination with other lipid-lowering treatments (e.g., LDL apheresis), or if those treatments are not possible. For patients with kidney failure, kidney disease does not affect the plasma concentration or LDL cholesterol-lowering effect of atorvastatin, thus there's no need for dose adjustment. For elderly patients, the efficacy and safety for those aged 70 and above are similar to that of the general adult population.

This medication should not be used in certain patients. For example, patients who have had allergies or hypersensitivity reactions to this drug or similar ingredients should not take it. Patients with severely impaired liver function or active liver disease should also avoid this medication. Women who are pregnant or may become pregnant should generally avoid this drug to minimize risks to the fetus, except in special cases. Furthermore, nursing women should also refrain from taking this medication. Patients with muscle-related diseases, severe aortic stenosis, cardiac shock, or within one month of a myocardial infarction should also avoid this drug. This medication should be used cautiously in patients with severely impaired kidney function, elderly individuals, alcoholics, and those with a history of liver disease. In particular, those at risk of muscle damage should have their muscle enzyme levels checked prior to treatment and monitored carefully. Those with heart failure, hypertensive crisis, or mild to moderate liver dysfunction should also exercise caution. Generally, this medication is well tolerated, but symptoms such as fatigue, swelling, dizziness, headache, and dyspepsia may occur. Rarely, side effects such as myalgia, skin rash, and liver function abnormalities may arise, so it is essential to consult a doctor if symptoms occur. This drug may affect liver function, necessitating regular liver function tests before and during treatment. If muscle pain or weakness occurs, promptly notify healthcare professionals and discontinue the medication as necessary. This drug may interact with other medications; therefore, always inform your doctor or pharmacist about any other medications being taken, especially when using certain antibiotics, antifungals, immunosuppressants, and HIV treatments. Pregnant or nursing women should not use this medication and should immediately inform a doctor if pregnancy occurs during treatment. The safety and efficacy of this medication have not been sufficiently established in children and elderly individuals, so special caution is warranted in these age groups. In the event of an overdose, immediately visit a medical facility for appropriate treatment and closely monitor blood pressure and cardiac function. This medication should be kept out of reach of children, and transferring it to other containers may impair quality, so caution is advised.

Serious side effects

• Urticaria
• angioedema
• toxic epidermal necrolysis
• severe swelling
• skin peeling
• blisters
• severe allergic reactions
• severe skin adverse reactions
• difficulty breathing
• asthma attacks

Mild side effects

• Flushing
• fatigue
• swelling
• palpitations
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• weakness

This medication should be stored at a temperature between 15 to 30 degrees Celsius, and it is important to keep it in a tightly sealed container to prevent air exposure. This helps maintain the drug's effectiveness and prevent degradation.

Appearance

White oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle