Medication info
Megesia Tablets 40mg (Megestrol Acetate)

Megesia Tablets 40mg (Megestrol Acetate)

Prescription medicationTabletOral
Ingredient · strength
Megestrol Acetate›40mg / 1 tablet
Manufacturer / importer
(Ltd.) Darim Biotech
Appearance
White round tablet
Packaging
Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle, PTP - 100 tablets/PTP [(10 tablets/PTP x 10)]
Approval status
Active

MFDS item code 200807473 · Notified 2008.07.07 · Insurance code 664601240

Summary

Main use
Palliation of cancer (breast cancer and endometrial cancer); treatment of cancer- and AIDS-related symptoms (such as loss of appetite)
Who takes it
Adults
Adult dose
1. Breast cancer : Administer megestrol acetate orally at a dose of 160mg per day, divided into 4 doses (40mg, 1 tablet per dose, 4 times daily). 2. Endometrial cancer : Administer this drug orally at a dose of 40~320mg per day in divided doses. 3. Treatment of anorexia, cachexia, or significant unexplained weight loss in patients with cancer or AIDS : Administer megestrol acetate orally at a dose of up to 800mg once daily. In clinical trials, clinical benefit was demonstrated with megestrol acetate doses of 400~800 mg per day. Treatment should be continued for at least 2 months, an appropriate period for assessing the effect of this drug.

Ingredients

Manufacturer
(Ltd.) Darim Biotech

Efficacy & effects

Palliation of cancer (breast cancer and endometrial cancer); treatment of cancer- and AIDS-related symptoms (such as loss of appetite)

  • Recurrent breast cancer
  • metastatic breast cancer
  • inoperable breast cancer
  • endometrial cancer
  • anorexia
  • cachexia
  • significant weight loss
View approved original text

This medication assists in symptom relief for patients with recurrent, metastatic, and inoperable breast cancer and endometrial cancer. It is not intended to replace surgical or radiation treatments. Additionally, it is used to treat anorexia, cachexia, and unexplained severe weight loss in patients with cancer or AIDS. This drug helps improve the quality of life for patients in these situations.

How to take

Adult dose

1. Breast cancer : Administer megestrol acetate orally at a dose of 160mg per day, divided into 4 doses (40mg, 1 tablet per dose, 4 times daily). 2. Endometrial cancer : Administer this drug orally at a dose of 40~320mg per day in divided doses. 3. Treatment of anorexia, cachexia, or significant unexplained weight loss in patients with cancer or AIDS : Administer megestrol acetate orally at a dose of up to 800mg once daily. In clinical trials, clinical benefit was demonstrated with megestrol acetate doses of 400~800 mg per day. Treatment should be continued for at least 2 months, an appropriate period for assessing the effect of this drug.

Precautions

This medication can cause serious harm to the fetus if taken during pregnancy, so it must absolutely not be taken during the first 4 months of pregnancy. Taking this medication during the first 4 months of pregnancy may increase the risk of fetal malformations, so women who are pregnant or may become pregnant should avoid its use. This drug may worsen diabetes, and long-term use may lead to adrenal insufficiency or Cushing's syndrome, requiring caution. Patients with a history of allergic reactions to this medication or its components, pregnant women, nursing mothers, and those with specific genetic lactose metabolism disorders should not take this medication. Patients with a history of thrombosis or diabetes should be observed more carefully when using this medication. While taking this drug, adverse reactions related to breast cancer and endometrial cancer may occur, and various side effects such as nausea, vomiting, blood pressure changes, hair loss, and fatigue have been reported. If this drug is taken during pregnancy or if pregnancy is confirmed while taking it, there is a risk of fetal malformation, and immediate consultation with healthcare professionals is necessary. If nursing, it is recommended to discontinue breastfeeding as this medication may be transmitted through breast milk and pose risks to the baby. Safety in children has not been established, so it is advisable that children do not take this medication. No special harmful symptoms have been reported with overdose, but due to the difficulty of drug removal through dialysis, appropriate treatment should be sought immediately at a hospital. This medication should be kept out of reach of children, and it is essential to avoid transferring it to other containers.

Side effects

  • Thrombophlebitis
  • thromboembolism
  • pulmonary embolism
  • glucose intolerance
  • heart failure
  • nausea
  • vomiting
  • edema
  • acute uterine bleeding
  • dyspnea
Show 68 more
  • tumor flush
  • hypercalcemia
  • hyperglycemia
  • alopecia
  • hypertension
  • carpal tunnel syndrome
  • mood changes
  • flushing
  • fatigue
  • asthenia
  • drowsiness
  • sweating
  • rash
  • gynecomastia
  • hearing loss
  • pain
  • Cushingoid facies
  • diarrhea
  • erectile dysfunction
  • abdominal bloating
  • asthenia
  • insomnia
  • anemia
  • fever
  • decreased libido
  • indigestion
  • headache
  • pneumonia
  • frequent urination
  • amblyopia
  • constipation
  • dry mouth
  • hepatomegaly
  • increased salivation
  • oral candidiasis
  • cardiomyopathy
  • palpitations
  • cough
  • pharyngitis
  • pulmonary dysfunction
  • leukopenia
  • proteinuria
  • incontinence
  • urinary tract infection
  • paresthesia
  • confusion
  • convulsions
  • depression
  • neuropathy
  • sensory loss
  • abnormal thoughts
  • herpes
  • itching
  • bullous rash
  • skin disorders
  • elevated LDH
  • edema
  • peripheral edema
  • chest pain
  • abdominal pain
  • infection
  • candidiasis
  • sarcoma
  • spontaneous bleeding
  • anxiety
  • stomatitis
  • mucositis
  • shoulder pain

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to prevent exposure to air, and it is best to keep it at room temperature between 15 degrees Celsius and 25 degrees Celsius. Storing it this way helps maintain the drug's effectiveness and prevents deterioration.

Appearance and packaging

Appearance

White round tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle, PTP - 100 tablets/PTP [(10 tablets/PTP x 10)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.