Letrizine Solution (Levocetirizine Hydrochloride)

Adult dose

For adults and children over 6 years of age: 5 mg (10 mL as a liquid form) of Levocetirizine Hydrochloride taken orally once daily, regardless of meals. Patients with renal impairment may need dosage adjustments based on their eGFR: - Normal renal function (≥90): 5 mg once daily - Mild renal impairment (60 －<90): 5 mg once daily - Moderate renal impairment (30－<60): 5 mg,

Child dose

For children aged over 2 and under 6 years: 1.25 mg (2.5 mL in liquid form), administered orally twice daily. For children aged over 1 and under 2 years: 1.25 mg (2.5 mL in liquid form), administered orally once daily.

This medication should not be used by patients who are allergic to certain ingredients or have had hypersensitivity reactions to hydroxyzine or piperazine derivatives in the past. Patients with end-stage renal disease or those undergoing hemodialysis should not take this medication. It should not be administered to infants under 1 year of age, and children under 6 years of age should only receive it in liquid form, not as tablets. The liquid formulation contains maltitol, which should not be used by patients with hereditary fructose intolerance. Patients with kidney or liver function issues, and elderly patients, should be cautious as this medication may increase blood levels. This medication may cause neurological symptoms such as drowsiness, headache, dizziness, and fatigue. Gastrointestinal symptoms such as nausea, abdominal pain, and diarrhea may also occur, so it is important to monitor one's condition closely. Increased or irregular heart rate may occur, and there may be changes in blood cell counts, so any unusual symptoms should be reported. Allergic reactions may manifest as skin rash, itching, or swelling, so caution is advised. Rarely, symptoms such as blurriness or conjunctival redness may appear, so eye health should also be checked. Periodic evaluations may be necessary as this medication may affect liver or kidney function. In children, febrile illness, diarrhea, vomiting, or otitis media may occur frequently, so consultation with a healthcare professional is advised upon appearance of unusual symptoms. Drowsiness or fatigue may occur, so caution is required during activities such as driving or operating machinery. When taken with alcohol or other central nervous system depressants, drowsiness may be exacerbated, so it is advisable to avoid concurrent use. Patients with difficulty in urinary excretion may see worsening of symptoms, so it should be used with caution. Patients with epilepsy or those at risk of seizures may experience worsening of symptoms if taking this medication, so caution is necessary. The liquid formulation contains preservatives and sweeteners, which may provoke allergic reactions or health issues, so one should check the ingredients. Pregnant women should consult a physician before using this medication as safety data is limited. Breastfeeding women should also take care as adverse reactions may occur in their infants. Children and the elderly may have decreased kidney function, necessitating dosage adjustments, and any unusual symptoms should be immediately reported. This medication may interfere with allergy tests, so stopping it before testing is advisable. In the event of overdose, symptoms such as drowsiness and agitation may occur, and there is no specific antidote, so treatment should be based on the symptoms. This medication cannot be removed by hemodialysis, so if an overdose occurs, appropriate medical care must be sought.

Serious side effects

Urticaria, severe swelling (edema), angioedema, anaphylactic shock, difficulty breathing, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, severe skin adverse reactions, elevated blood pressure, liver dysfunction (jaundice), hepatitis, severe swelling or urinary issues, headache, seizures, visual disturbances, paralysis, convulsions, respiratory distress, cough with fever accompanied respiratory abnormalities, hypertension

Mild side effects

• Drowsiness
• lethargy
• headache
• numbness
• agitation
• somnolence
• fatigue
• dizziness
• heaviness in the head
• excitement

This medication is sensitive to light and should be stored in a light-resistant container. Additionally, it is important to maintain a room temperature, specifically between 1 degree and 30 degrees Celsius, while storing the medication. This helps preserve its effectiveness and safety over time.

Appearance

A colorless and transparent solution in a brown glass bottle or plastic container

Package unit

1 bottle/box [100 mL/bottle], 500 milliliters/bottle