Diamicron MR (Gliclazide)

Adult dose

Adults: Administer gliclazide at a dose of 30 to 120 mg once daily in the morning, adjusted according to blood glucose levels. It is recommended to swallow the medication whole without breaking or chewing it. If a dose is missed, do not double the next day's dose. The initial recommended dose is 30 mg daily. If blood glucose control is unsatisfactory, it may be gradually increased to 60, 90, or 120 mg at least one month apart.

This medication is a sulfonylurea, which can cause hypoglycemia; therefore, blood glucose levels must be closely monitored while taking it. It should not be administered to certain patients such as those with diabetic ketoacidosis, type 1 diabetes, severe liver or kidney dysfunction, severe infections, and patients undergoing surgery, nor should it be taken by pregnant or breastfeeding women. During the use of this medication, a decrease in food intake or gastrointestinal disturbances such as vomiting or diarrhea can increase the risk of hypoglycemia, so caution is necessary. Elderly patients or those with compromised kidney or liver function, as well as patients with poor nutrition or irregular eating habits, should also use it cautiously. Symptoms of hypoglycemia may include lethargy, headache, tremors, confusion, drowsiness, and in severe cases may lead to altered consciousness, seizures, or coma, hence immediate consultation with medical personnel is required. This medication may interact with other drugs; therefore, blood glucose fluctuations should be closely observed when taken concurrently with miconazole, alcohol, certain anti-inflammatory drugs, antihypertensives, antibiotics, etc. Women who are pregnant or planning to become pregnant are advised to use insulin therapy instead, and breastfeeding women should also avoid using this medication. Safety for children has not been established; hence, its use is not recommended. Overdose may lead to hypoglycemia, and if symptoms appear, immediate glucose intake or emergency measures should be taken. During the initial dosing phase, it is important to be well informed about hypoglycemia symptoms and to be cautious when driving or operating machinery. Store this medication out of reach of children, and do not transfer it to another container.

Serious side effects

• Urticaria
• severe swelling (edema)
• jaundice
• large blister rash
• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• drug rash (DRESS).

Mild side effects

• Weakness
• intense hunger
• tremors
• headache
• altered perception
• excitement
• decreased concentration
• aggression
• nausea
• vomiting

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. It is recommended to maintain the storage temperature between 1 and 30 degrees Celsius.

Appearance

White oblong modified-release tablet

Package unit

500 tablets/bottle, 60 tablets (30 tablets/PTP x 2)