Medication info
Lyrica Tablets (Riluzole)

Lyrica Tablets (Riluzole)

Prescription medicationTabletOral
Ingredient · strength
Riluzole›50mg / 1 tablet
Manufacturer / importer
SANOFI-AVENTIS KOREA CO., LTD.
Appearance
White oblong film-coated tablet with RPR202 engraved on one side.
Packaging
56 tablets/box [28 tablets/blister x 2]
Approval status
Active

MFDS item code 200805962 · Approved 2008.05.28 · Insurance code 652000220

Summary

Main use
Treatment of amyotrophic lateral sclerosis (prolongs survival and delays tracheostomy)
Who takes it
Adults
Adult dose
The recommended dose for adults and elderly patients is 100mg per day, administered as 50mg every 12 hours. Increasing the dose is not expected to provide any particular additional benefit, but may increase adverse reactions. To avoid a reduction in bioavailability caused by food, take this medicine at least 1 hour before or 2 hours after a meal.

Ingredients

Importer
SANOFI-AVENTIS KOREA CO., LTD.

Efficacy & effects

Treatment of amyotrophic lateral sclerosis (prolongs survival and delays tracheostomy)

View approved original text

This medication helps prolong the survival of patients with amyotrophic lateral sclerosis and delays the timing of tracheostomy for use of a ventilator. It helps maintain the quality of life for patients and delays the progression of symptoms.

How to take

Adult dose

The recommended dose for adults and elderly patients is 100mg per day, administered as 50mg every 12 hours. Increasing the dose is not expected to provide any particular additional benefit, but may increase adverse reactions. To avoid a reduction in bioavailability caused by food, take this medicine at least 1 hour before or 2 hours after a meal.

Precautions

This drug may affect liver function, so patients with liver damage or abnormal liver function should exercise special caution. Regular liver function tests should be performed before and during treatment, and if liver enzyme levels are elevated, the doctor should be consulted immediately. During the use of this drug, blood abnormalities such as neutropenia may occur, so if there are symptoms of fever or infection, the doctor should be informed immediately. If respiratory symptoms, such as a dry cough or difficulty breathing, develop, chest X-rays should be conducted due to the possibility of interstitial lung disease, and in this case, the medication should be discontinued. Patients with hypersensitivity to this drug or severely impaired liver function, as well as pregnant or nursing women, should not take this medication. Patients with decreased liver and kidney function should use this drug with caution and follow the doctor's instructions. This medication may cause side effects such as fatigue, nausea, dizziness, diarrhea, and loss of appetite, so if symptoms worsen, consult a doctor. Take this medication regularly at the same time every day, and if a dose is missed, take the next dose as scheduled. This drug may affect mental or motor abilities, so it is advisable to avoid driving or operating machinery after taking it. Alcohol can increase the risk of liver toxicity, so it is important not to consume large amounts. There may be interactions when taken with other medications, so if you are taking other medications, be sure to inform your doctor or pharmacist. Pregnant or nursing women should not use this drug, and if planning to become pregnant or if pregnant, must consult a doctor. Elderly patients may have a higher risk of decreased liver and kidney function, thus requiring extra caution when taking this medication. The safety and efficacy in children have not been established, so this medication should not be used in children. In cases of overdose, neurological symptoms and blood abnormalities may manifest, requiring immediate medical attention and appropriate treatment if necessary. Store this medication out of reach of children and keep it in its original container.

Side effects

  • Liver failure
  • elevated serum transaminase
  • elevated bilirubin
  • jaundice
  • significant neutropenia
  • anemia
  • complex blood abnormalities
  • dry cough
  • dyspnea
  • malaise
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  • nausea
  • dizziness
  • decreased lung function
  • diarrhea
  • abdominal pain
  • pneumonia
  • vomiting
  • vertigo
  • oral paresthesia
  • decreased appetite
  • drowsiness
  • constipation
  • headache
  • lower back pain
  • fatigue
  • vomiting
  • indigestion
  • bloating
  • gastritis
  • dental damage
  • oral candidiasis
  • tension
  • depression
  • dry mouth
  • insomnia
  • perioral paresthesia
  • pruritus
  • eczema
  • alopecia
  • exfoliative dermatitis
  • rhinitis
  • cough
  • sinusitis
  • hypertension
  • tachycardia
  • phlebitis
  • palpitations
  • orthostatic hypotension
  • weight loss
  • peripheral edema
  • arthralgia
  • urinary tract infection
  • dysuria
  • injury due to accident
  • apnea
  • bronchitis
  • death
  • dysphagia
  • flu-like symptoms
  • cardiac arrest
  • increased sputum
  • respiratory disorders
  • hostility
  • abscess
  • sepsis
  • photosensitivity reaction
  • angioedema
  • facial swelling
  • hernia
  • peritonitis
  • suicide attempt
  • injection site reaction
  • chills
  • flu-like symptoms
  • self-harm
  • abdominal enlargement
  • tumor
  • tenderness
  • hypothermia
  • candidiasis
  • rheumatoid arthritis
  • increased appetite
  • bowel obstruction
  • fecal impaction
  • gastrointestinal bleeding
  • gastrointestinal ulcers
  • loss of consciousness
  • jaundice
  • hepatitis
  • glossitis
  • gum bleeding
  • pancreatitis
  • late stage
  • esophageal stricture
  • cheilitis
  • cholecystitis
  • hematemesis
  • melena
  • biliary pain
  • proctitis
  • membranous enterocolitis
  • salivary gland enlargement
  • tongue discoloration
  • dental bone loss
  • anxiety
  • tremors
  • hallucinations
  • personality disorder
  • thought disorder
  • coma
  • dissociative reaction
  • affective disorder
  • ataxia
  • extrapyramidal syndrome
  • decreased motor function
  • urinary retention
  • emotional instability
  • delusion
  • emotional blunting
  • sensory impairment
  • disharmony
  • confusion
  • convulsions
  • leg cramps
  • forgetfulness
  • speech disorder
  • increased libido
  • confusion
  • subdural hematoma
  • gait disturbance
  • incoherence
  • depersonalization
  • facial paralysis
  • hemiplegia
  • decreased libido
  • hepatosteatosis
  • strange dreams
  • acute encephalopathy
  • CNS depression
  • dementia
  • cerebral embolism
  • hypertrichosis
  • decreased muscle tone
  • bowel obstruction
  • peripheral neuropathy
  • psychosis
  • psychotic depression
  • dissociative reaction
  • mouth opening disorder
  • hand tremor
  • skin ulcer
  • urticaria
  • psoriasis
  • seborrhea
  • skin disorders
  • fungal dermatitis
  • angioedema
  • contact dermatitis
  • erythema multiforme
  • albinism
  • skin candidiasis
  • skin granuloma
  • skin nodules
  • hiccups
  • pleural disorder
  • asthma
  • epistaxis
  • hemoptysis
  • yawning
  • hyperventilation
  • pulmonary edema
  • respiratory depression
  • lung cancer
  • hypoxia
  • laryngitis
  • pleural effusion
  • pneumothorax
  • respiratory candidiasis
  • wheezing
  • syncope
  • hypotension
  • heart failure
  • migraine
  • peripheral vascular disease
  • angina
  • myocardial infarction
  • ventricular premature contraction
  • cerebral hemorrhage
  • atrial fibrillation
  • block
  • congestive heart failure
  • pericarditis
  • peripheral embolism
  • myocardial ischemia
  • shock
  • bradycardia
  • cerebral ischemia
  • hemorrhage
  • mesenteric artery occlusion
  • subarachnoid hemorrhage
  • loss of performance tachycardia
  • thrombosis
  • ventricular fibrillation
  • ventricular tachycardia
  • gout
  • respiratory acidosis
  • edema
  • thirst
  • hypokalemia
  • hyponatremia
  • weight gain
  • generalized edema
  • hypercalcemia
  • hypercholesterolemia
  • diabetes
  • goiter
  • diabetes insipidus
  • parathyroid disorder
  • anemia
  • leukocytosis
  • leukopenia
  • petechiae
  • neutropenia
  • aplastic anemia
  • cyanosis
  • hypopigmented anemia
  • iron deficiency anemia
  • lymphadenopathy
  • punctate hemorrhage
  • purpura
  • arthropathy
  • myasthenia gravis
  • osseous neoplasm
  • osteonecrosis
  • osteoporosis
  • spasm
  • amblyopia
  • ocular inflammation
  • blepharitis
  • cataract
  • hearing loss
  • diplopia
  • otalgia
  • glaucoma
  • auditory hypersensitivity
  • photophobia
  • loss of taste
  • vestibular disorder
  • urgency
  • urinary abnormalities
  • urinary incontinence
  • kidney stones
  • hematuria
  • erectile dysfunction
  • prostatic carcinoma
  • renal colic
  • abnormal uterine bleeding
  • persistent erection
  • amenorrhea
  • breast abscess
  • mastalgia
  • nephritis
  • nocturia
  • pyelonephritis
  • uterine fibroids
  • uterine bleeding
  • vaginal candidiasis
  • gamma-glutamyl transferase increase
  • abnormal liver function
  • alkaline phosphatase increase
  • positive Kuhn test
  • increase in gamma globulin
  • increase in lactate dehydrogenase
  • acute encephalopathy
  • methemoglobinemia

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light, so it should be stored in a container that protects it from light. Furthermore, it is important to store it at a cool temperature below 25 degrees Celsius to maintain its effectiveness.

Appearance and packaging

Appearance

White oblong film-coated tablet with RPR202 engraved on one side.

Package unit

56 tablets/box [28 tablets/blister x 2]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.