Hyalu Injection (Sodium Hyaluronate) (Pre-filled)

Adult dosage

As sodium hyaluronate, administer 25mg once a week for 5 consecutive weeks intra-articularly into the knee joint or shoulder joint, adjusting frequency based on symptoms. This medication is administered intra-articularly under strict aseptic procedures.

This medication should not be used in patients with a history of hypersensitivity. This medication should not be used if there is a skin condition or infection at the injection site. Patients with liver function problems or a history of liver disease should exercise caution before using this medication. Patients allergic to avian proteins should also avoid this medication. There is a potential for shock when receiving this medication, so patients should be closely monitored after administration, and if adverse reactions occur, administration should be stopped immediately and treatment should be sought. Allergic reactions such as swelling or redness around the face or eyes, rashes, hives, or itching may occur, so if these symptoms appear, use should be stopped and appropriate measures should be taken. Temporary pain, swelling, redness, warmth, severe pressure sensation, or bruising may occur at the injection site, so this should be taken into account. Nausea, vomiting, fever, and headache may rarely occur as well. In cases of severe arthritis, it is advisable to administer this medication after inflammation has subsided. Stabilizing the joint after administration helps alleviate pain. Care should be taken to ensure the injection is accurately administered within the joint, as leakage outside the joint may cause pain. Patients with inflammatory arthritis may experience temporary worsening of inflammation after administration, so caution is advised. It is best to avoid vigorous exercise or prolonged weight-bearing activities within 48 hours after administration. Combining this injection with other intra-articular injections is not recommended due to unconfirmed safety and efficacy. Women who are pregnant or may become pregnant should carefully weigh the risks and benefits before using this medication. If breastfeeding, it is advisable to avoid nursing during administration as this medication may be transmitted through breast milk. Safety has not been established in children, so it should be used cautiously only when necessary. Elderly patients should be monitored closely as physical functions may be weakened. Maintain aseptic conditions during injection, and limit to 5 administrations if symptoms do not improve. If there is excess synovial fluid, it is advisable to drain it before injection. Intra-vascular injections are prohibited, and it is not intended for ophthalmic use. Use appropriate syringes for injection, and take care to ensure that the solution in the ampule is well aspirated. When opening the ampule, use clean tools to prevent contamination, and take care as precipitation may occur if mixed with disinfectants. This medication is for single use only; any unused portion should be discarded immediately after opening.

Serious side effects

• Shock
• hives
• swelling
• severe allergic reactions

Mild side effects

• Swelling (facial, eyelid, etc.)
• facial flushing
• rash
• hives
• itching
• pain
• enlargement
• redness
• warmth
• severe local pressure sensation

This medication is sensitive to light and should be stored in a special container that blocks light. Additionally, it is important to maintain a room temperature of between 1 degree and 30 degrees Celsius while storing the medication. Storing it this way helps preserve its efficacy and safety.

Appearance

A colorless, transparent, viscous liquid contained in a glass tube sealed with rubber stoppers at both ends (part of a pre-filled syringe system).

Package unit

(2.5mL/1 syringe)*5 syringes