Astheril Plus Arginine Tablets

Adult dose

○ Adults: Before administering this drug, it is recommended that the doses of perindopril or indapamide be adjusted as monotherapy. This drug should be administered only to patients whose blood pressure is not adequately controlled with the individual components, at a dose of perindopril arginine 5 mg/indapamide 1.25 mg orally once daily before breakfast. ○ Patients with renal impairment This drug is contraindicated in patients with severe renal impairment (creatinine clearance < 30 mL/min). Patients with moderate renal impairment (creatinine clearance 30 ～ 60 mL/min) should begin treatment with an appropriate dose of each component. No dose adjustment is required if creatinine clearance is 60 mL/min or higher, but continued monitoring of creatinine and potassium concentrations is necessary. ○ Patients with hepatic impairment This drug is contraindicated in patients with severe hepatic impairment. No dose adjustment is necessary in patients with moderate hepatic impairment.

This medication can cause serious harm to the fetus during pregnancy, so it should be discontinued immediately if pregnancy is confirmed. One of the ingredients in this medication may reduce blood cell counts in patients with weakened immune systems, necessitating regular blood tests, and any signs of infection should be reported immediately. Angioedema, which involves swelling of the face, lips, or tongue, may rarely occur, so if these symptoms appear, the medication should be stopped immediately, and medical advice should be sought. Patients receiving treatment for bee venom allergy should be cautious as this medication may cause severe allergic reactions; if necessary, the medication may need to be stopped for a period before treatment. For patients undergoing dialysis with specific dialysis membranes, taking this medication may be risky, so it’s important to consult with healthcare providers regarding dialysis methods. Patients with severely impaired liver function should be cautious with this medication as some ingredients can induce hepatic encephalopathy, and photosensitivity may cause skin abnormalities, so sun exposure should be avoided. This medication should not be administered to patients with specific diseases or conditions, such as those with severely impaired renal function, high potassium levels, a history of angioedema, children, or pregnant women. Particularly in elderly patients with impaired kidney or heart function, those with diabetes, and those with severe hypertension, treatment should begin at low doses and be closely monitored. During treatment, it is essential to regularly check blood pressure, kidney function, and electrolyte levels to ensure there are no abnormalities. Caution is advised while driving or operating machinery as dizziness or drowsiness may occur. Some drugs may pose a risk when taken together; therefore, inform healthcare providers if you are taking any other medications. In cases of overdose, symptoms such as severe hypotension, nausea, vomiting, dizziness, etc., may occur, necessitating immediate medical attention and possible emergency treatment. Finally, this medication should be kept out of reach of children and stored away from moisture and direct sunlight.

Neutropenia, agranulocytosis, thrombocytopenia, anemia, vascular edema, facial swelling, limb swelling, lip swelling, tongue swelling, glottic edema, laryngeal edema, airway obstruction, dizziness, headache, sensory disturbance, taste disturbance, visual impairment, vertigo, tinnitus, hypotension, cough, dyspnea, abdominal pain, constipation, dyspepsia, diarrhea, nausea, vomiting, pruritus, rash, muscle cramps, weakness, hypersensitivity reaction, asthma-like reaction, papular rash, rhinitis, eosinophilia, aplastic anemia, pancytopenia, leukopenia, hemolytic anemia, thrombocytopenia, hypoglycemia, hyperkalemia, hyponatremia, hypercalcemia, hypokalemia, hypochloremia, hypomagnesemia, syndrome of inappropriate antidiuretic hormone secretion, mood disorders, sleep disorders, confusion, depression, drowsiness, syncope, secondary stroke due to excessive blood pressure reduction in high-risk patients, hepatic encephalopathy, visual impairment, myopia, acute closed-angle glaucoma, choroidal exudate, blurred vision, vertigo, tinnitus, palpitations, tachycardia, angina, arrhythmia, hypotension, vasculitis, Raynaud's phenomenon, bronchial spasm, eosinophilic pneumonia, thirst, pancreatitis, hepatitis, abnormal liver function, urticaria, purpura, hyperhidrosis, photosensitivity reaction, pseudo-dermatitis herpetiformis, eczema, psoriasis, multiple erythema, toxic epidermal necrolysis, Stevens-Johnson syndrome, flushing, myalgia, muscle weakness, rhabdomyolysis, renal insufficiency, acute kidney failure, renal failure, anuria, erectile dysfunction, chest pain, lethargy, peripheral edema, fever, fatigue, elevated blood urea, elevated blood creatinine, elevated serum bilirubin, elevated liver enzyme levels, decreased hemoglobin, increased blood glucose, elevated serum uric acid, QT interval prolongation on electrocardiogram, falls, nitrite response, respiratory distress due to angioedema, airway and tongue swelling due to angioedema, abdominal pain due to angioedema

This medication may be sensitive to air and moisture; thus, it should be stored in a tightly sealed container. The storage temperature should be kept at room temperature between 1 degree and 30 degrees Celsius. This helps to maintain the effectiveness of the medication for a longer period.

Appearance

White rectangular film-coated tablet

Package unit

30 tablets / bottle