Aeron Plus Injection (Sodium Hyaluronate) (Pre-filled)

Adult administration

Typically, 1 syrette is administered once a week for 3 consecutive weeks into the knee joint or shoulder joint (joint space, subacromial bursa, or tendon sheath of the biceps brachii) but the dosing frequency should be adjusted according to symptoms.

This drug should not be used in patients who have experienced allergic reactions to its ingredients. Patients with allergies to other medications or those with liver function issues should exercise special caution when using this drug. Cases of elevated liver enzymes have been reported in patients with prior liver dysfunction. As this drug is injected directly into the joint, care should be taken when using it in the presence of skin diseases or infections at the injection site. Rarely, severe allergic reactions, including shock, may occur following administration of this drug, so patients should be closely monitored after injection, and if any abnormal symptoms arise, administration should be immediately discontinued, and appropriate treatment should be sought. Additionally, allergic symptoms such as swelling, redness, rash, hives, and itching around the face or eyes may occur; if such symptoms appear, use should be discontinued, and treatment should be sought. Temporary pain, swelling, redness, warmth, and a feeling of pressure may occur at the injection site, and symptoms such as nausea, vomiting, and fever may also arise. If there is significant inflammation in the joint, it is advisable to reduce the inflammation before using this drug. Stabilizing the injection site after administration may be helpful. If the medication leaks outside the joint, pain may occur, so it must be accurately injected into the joint. Injections should be performed in a clean and sterile environment, and if no therapeutic effect is observed, administration should be limited to 3 injections and then discontinued. If there is fluid accumulation in the joint, it is preferable to aspirate the fluid before administration. This drug should not be used for intravenous or ophthalmic administration, and a 22-23 gauge needle is recommended. It should not be mixed with disinfectants such as benzalkonium chloride or chlorhexidine, as they can react with the drug and cause precipitation. Pregnant women or those who may become pregnant should use this drug cautiously, only when the benefits outweigh the risks, and it is advisable to avoid use during breastfeeding, as the drug may pass into breast milk. The safety of this drug has not been sufficiently established in children, so it should only be used cautiously when necessary.

Serious side effects

• Hives
• swelling
• shock symptoms

Mild side effects

• Facial swelling
• facial redness
• rash
• itching
• pain
• swelling
• edema
• redness
• warmth
• localized pressure

This drug should be stored in a sealed container to prevent exposure to air, and the storage temperature should be maintained between 1 to 30 degrees Celsius to ensure the efficacy and safety of the drug.

Appearance

An injection filled in a colorless, transparent, viscous liquid contained in a colorless, transparent glass tube sealed with rubber caps at both ends (part of the Pre-filled syringe system)

Package unit

3 syrettes (2mL/syrettes x 3)