Aricept Aves Tablet 10mg (Donepezil Hydrochloride)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. For 4 to 6 weeks, administer the 5 mg dose. After evaluating clinical responses during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg, take care with gastrointestinal adverse reactions. This medication can be taken as an oral disintegrating tablet, dissolving it on the tongue with or without water.

Child dose

There is no experience of use in children.

This medication contains donepezil hydrochloride as its active ingredient and is used for the treatment of symptoms of Alzheimer's type dementia. First, this medication should not be administered to patients who are allergic to donepezil hydrochloride or similar components, to women who are pregnant or may become pregnant, and to nursing mothers. Caution is required for patients with heart disease, particularly those with sinus bradycardia or heart conduction disorders, as this medication may cause a slower heart rate or arrhythmias. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should use this medication cautiously as it may increase gastric acid secretion and promote gastrointestinal motility, which could worsen ulcer symptoms. Patients with a history of asthma or obstructive pulmonary disease should be cautious as this medication may constrict bronchial muscles and increase mucus secretion, worsening symptoms. Patients with extrapyramidal disorders such as Parkinson’s disease should have caution when taking this medication, as it may exacerbate symptoms. Serious side effects may occur during the use of this medication, including fainting, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, cerebrovascular disorders, movement disorders, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute kidney failure, and sudden death; consult a doctor immediately if any abnormal symptoms arise. Common side effects may also include nausea, vomiting, diarrhea, loss of appetite, dizziness, insomnia, hallucinations, anxiety, myalgia, headache, sweating, skin rash, eczema, itching, hives, fever, edema, thrombocytopenia, anemia, urinary incontinence, urination disorders, elevated blood pressure, blood pressure fluctuations, difficulty swallowing, urinary retention, liver dysfunction, hepatitis, abnormal liver function, dehydration, hypotension, hypertension, and palpitations. Patients with heart disease or electrolyte imbalances, as well as those taking other drugs that prolong the QT interval, should periodically monitor their heart status through ECG. Pregnant or nursing women should avoid this medication, and even when necessary, it should be considered carefully after consulting with a professional. The safety of this medication in children has not been established, so it is not used in this population. Caution is needed while driving or operating machinery as fatigue, dizziness, and muscle cramps may occur. This medication is metabolized by certain enzymes (CYP3A4, CYP2D6), so caution is required when taken with drugs that inhibit or induce these enzymes. In case of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, and seizures may appear, and immediate appropriate treatment at a hospital is essential. When taking this medication, if using the oral disintegrating formulation, place it on the tongue to dissolve and take with saliva or water, keep out of reach of children, and store in the original packaging to prevent discoloration from light exposure.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, vision changes, paralysis, urination

Mild side effects

• Loss of appetite
• insomnia
• drowsiness
• nausea
• vomiting
• diarrhea
• abdominal pain
• fatigue
• headache
• dizziness

This medication should be stored in a tightly closed container, protected from air and moisture, and kept at room temperature between 1 and 30 degrees Celsius for safe storage. Storing it this way can maintain the medication’s effectiveness and prevent deterioration.

Appearance

Yellow round tablet

Package unit

30 tablets (10 tablets/PTP × 3)