Apen Tablet (Aceclofenac)

Adult dose

Adults: take 100 mg of aceclofenac once every 12 hours, for a total of 2 times a day. This medication should be taken whole, without chewing or breaking. Adjustment of the dose may be made according to symptoms. To minimize cardiovascular adverse reactions of this medication, the lowest effective dose should be given for the shortest duration.

This medication should be used cautiously in individuals who regularly consume more than three glasses of alcohol daily, as it may increase the risk of gastrointestinal bleeding; consultation with a doctor or pharmacist is essential. This medication may increase the risk of cardiovascular and cerebrovascular diseases, so individuals with cardiovascular risk factors such as heart disease, hypertension, diabetes, and smoking should use it carefully. The longer the dosage and duration, the higher the cardiovascular risks, so it is best to take the lowest effective dose for the shortest duration possible. Serious gastrointestinal adverse reactions such as gastrointestinal bleeding, ulcers, and perforations may occur, especially in the elderly or those with a history of gastrointestinal diseases. Patients with active peptic ulcers, severe heart failure, severe renal and hepatic impairment, late-term pregnancy, breastfeeding, or bleeding disorders should not take this medication. Patients with renal or liver dysfunction, hypertension, asthma, elderly individuals, women in early or mid-pregnancy, or those taking anticoagulants should use this medication cautiously. This medication may cause side effects such as dizziness, gastrointestinal discomfort, elevated liver enzyme levels, skin rashes, and rarely, severe allergic reactions, hepatitis, or kidney damage. If abnormal symptoms occur during use, contact a doctor immediately; particularly if symptoms such as skin rashes or breathing difficulties arise, stop taking the medication immediately. This medication may interact with other drugs; if taking digoxin, anticoagulants, diabetes medications, diuretics, lithium, methotrexate, or other medications, inform the doctor. During pregnancy, especially in the last three months, this medication should be avoided as it may pose risks to the fetus, and it's advisable not to take it while breastfeeding. Safety in children and adolescents has not been established, so it is preferable not to use this medication in this population. Elderly patients are at increased risk for gastrointestinal bleeding and perforation, so special caution is needed when taking this medication. In case of overdose, symptoms such as gastrointestinal irritation, hypotension, respiratory depression, and seizures may appear, and immediate medical assistance should be sought. This medication should be stored out of reach of children and should not be transferred to another container for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash accompanied by high fever, blisters, skin shedding, pain in oral/ocular mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory difficulties accompanied by cough and fever, skin or eye jaundice (yellowing), extreme lethargy, liver abnormalities (jaundice), sudden and

Mild side effects

• Dizziness
• abnormal liver enzyme levels
• itching
• rashes
• anemia
• leukopenia
• thrombocytopenia
• neutropenia
• hemolytic anemia
• aplastic anemia

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius to safely preserve the medication's efficacy.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle, 500 tablets/bottle