Januvia Tablet 100 mg (Sitagliptin Phosphate Hydrate)

Adult dose

In monotherapy or combination therapy, administer 100 mg once daily, with a maximum daily dose of 100 mg. It can be taken without regard to meals. In patients with renal impairment, dosage adjustments are necessary based on kidney function. In patients with mild or moderate renal impairment (eGFR 45 or greater but less than 90), no dosage adjustment is required. In patients with moderate renal impairment (eGFR 30 or greater but less than 45), administer 50 mg once daily.

This drug may cause allergic reactions, so if symptoms such as rash, difficulty breathing, or swelling of the face or neck occur, discontinue use immediately and consult a doctor. Additionally, serious inflammation of the pancreas known as acute pancreatitis may occur, so if symptoms such as abdominal pain, nausea, or vomiting arise, promptly inform a healthcare provider. Do not use this medication in patients with type 1 diabetes or diabetic ketoacidosis, and avoid use if allergic to the drug or its components. Patients with decreased kidney function may have difficulty excreting this medication, so dosage adjustments or careful use may be necessary. Mild adverse reactions such as cold symptoms, headache, and nasopharyngitis may occur while taking this medication, and occasionally hypoglycemic symptoms may arise, so caution is advised. The risk of hypoglycemia may be increased when used in conjunction with other glucose-lowering agents such as insulin or sulfonylureas, necessitating dosage adjustments. If severe joint pain or symptoms such as blistering on the skin occur, inform a doctor immediately to discontinue the medication. Pregnant or breastfeeding women are advised not to use this medication, and safety in children under 18 years has not been established. Elderly patients may have decreased kidney function, so evaluation of kidney function before administration and periodic testing during treatment is needed. In case of overdose, immediately visit a medical institution for appropriate treatment, and this medication can be partially removed by hemodialysis if necessary.

Serious side effects

Severe hypersensitivity reactions (including hives, angioedema, anaphylaxis), Stevens-Johnson syndrome and exfoliative skin disorders, acute pancreatitis, acute renal failure, severe and disabling joint pain, vesicular pemphigoid, difficulty breathing, hives, angioedema, severe swelling (edema), severe allergic reactions, serious skin adverse reactions, severe edema or urination disorders.

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• constipation
• vomiting
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

Store this medication in a tightly sealed container with minimal air exposure, at room temperature between 1 and 25 degrees Celsius. This preserves the drug's efficacy and prevents degradation.

Appearance

A beige, round, biconvex, film-coated tablet engraved with 277 on one side.

Package unit

28 tablets (14 tablets/PTP x 2)