Ozatran Plus Tablet 100/12.5 mg

Adult dose

The usual dosage for adults is 50 mg of Losartan Potassium / 12.5 mg of Hydrochlorothiazide, taken once daily as one tablet. Doses exceeding 100 mg of Losartan Potassium / 25 mg of Hydrochlorothiazide daily are not desirable. For patients whose blood pressure is not controlled using losartan or hydrochlorothiazide monotherapy, treatment can be initiated with 50 mg of Losartan Potassium / 12.5 mg of Hydrochlorothiazide, taken once daily as one tablet.

Child dose

There is no experience in using this combination of losartan and hydrochlorothiazide in children and adolescents; therefore, it should not be administered to these age groups.

This medication can cause serious harm to the fetus and newborn, especially during pregnancy; therefore, it should not be used by women who are pregnant or may become pregnant. This medication may pose risks when administered to patients with certain diseases or conditions, such as those with anuria, electrolyte imbalance, severe liver impairment, severe renal impairment, patients on dialysis, or those with specific genetic metabolic disorders, among others. Patients with significantly low blood pressure or existing renal function issues, patients with a history of liver impairment, patients with hyperuricemia or gout, and elderly patients should exercise particular caution when using this medication. The hydrochlorothiazide component can cause electrolyte imbalance, so regular blood tests should be conducted to monitor electrolyte levels, and any symptoms that arise should prompt immediate consultation with a physician. This medication may cause side effects such as skin rash, angioedema, dizziness, cough, abdominal pain, and rarely, serious allergic reactions or liver dysfunction and worsening renal function. Due to potential drug interactions, especially with potassium-sparing diuretics, potassium supplements, certain antihypertensives, nonsteroidal anti-inflammatory drugs, and lithium preparations, patients should consult their physician if taking such medications together. While taking this medication, sudden onset of symptoms indicating low blood pressure or dizziness may occur, so caution is needed when driving or operating machinery. Women who are pregnant or planning to become pregnant must consult their physician before taking this medication and must immediately discontinue use if pregnancy is confirmed, as well as consider stopping breastfeeding if applicable. This medication is not recommended for use in children and adolescents due to a lack of established safety and efficacy. Elderly patients may have a higher risk of experiencing side effects and should be closely monitored when administered this medication. In case of overdose, symptoms such as hypotension, tachycardia, and electrolyte imbalance may occur, so the prescribed dosage should be strictly adhered to; if any unusual symptoms occur, immediate contact with a healthcare facility is necessary. This medication should be kept out of reach of children and stored in its original container to avoid misuse or quality degradation.

Serious side effects

Hives, severe swelling (edema), angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin shedding, pain in mouth/eyes mucosa, shortness of breath or breathing difficulties, asthma attacks, respiratory issues along with cough and fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances,

Mild side effects

• Abdominal pain
• edema/swelling
• palpitations
• back pain
• dizziness
• cough
• sinusitis
• upper respiratory infection
• weakness/fatigue
• diarrhea

This medication is sensitive to light and should be stored in a securely closed container that blocks light. It is important to maintain a storage temperature between 1°C and 30°C at room temperature.

Appearance

White to grayish oval coated tablet

Package unit

30 tablets/bottle