Dirole 400 mg (Dexibuprofen)

Adult dose

As dexibuprofen, take 400 mg orally 2 to 3 times a day. However, do not exceed 1,200 mg per day as dexibuprofen.

This medication can pose a risk of gastric bleeding if taken by individuals who regularly consume more than 3 alcoholic beverages daily; therefore, it is essential to consult a physician or pharmacist. It may affect the cardiovascular system, increasing the risk of myocardial infarction, stroke, etc., so special caution is needed for patients with cardiovascular diseases or risk factors. As a non-steroidal anti-inflammatory drug, this medication can cause serious adverse reactions such as gastric bleeding, ulcers, and perforation, and the risk may be greater for the elderly or those taking it over an extended period. Individuals with a history of gastrointestinal ulcers or bleeding, severe liver disease, kidney disease, heart failure, or hypertension should not take this medication, and those with allergies or asthma history should also avoid it. It is preferable to avoid using this medication concurrently with aspirin or other non-steroidal anti-inflammatory drugs, and caution is needed due to the potential for increased side effects from interactions with specific medications. During treatment, it is recommended to stop breastfeeding or discontinue medication, as dizziness or fatigue may occur, requiring caution when driving or operating machinery. Individuals with a history of blood abnormalities, liver disease, kidney disease, hypertension, heart failure, the elderly, children, and pregnant women should consult healthcare professionals prior to use. If symptoms such as shock, severe skin rashes, gastrointestinal bleeding, liver dysfunction, kidney problems, or neurological symptoms appear during treatment, discontinue immediately and consult a physician. Long-term use requires regular blood tests and liver and kidney function checks, and it should be used at the minimum effective dose for as short a duration as possible. After 20 weeks of pregnancy, there is a risk of fetal kidney dysfunction and oligohydramnios, so it should be used with caution, and immediate medical attention is required in case of overdose. Keep this medication out of reach of children, store it away from direct sunlight, and keep it in a cool, dry place.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor → severe allergic reactions
• Severe rash with high fever, blisters, skin peeling, mucosal pain in mouth/eyes → severe skin reactions
• Asthma attacks, breathing difficulties accompanied by cough and fever → respiratory issues
• Yellowing of the skin or eyes (jaundice), extreme lethargy → liver issues (jaundice)
• Sudden and severe headaches, thunderclap headaches

Mild side effects

• Dyspepsia
• abdominal bloating
• heartburn
• diarrhea
• constipation
• loss of appetite
• nausea
• vomiting
• abdominal pain
• gastric discomfort

This medication may be sensitive to air and moisture, so it must be stored in a sealed container. Additionally, it is advisable to keep it at room temperature (between 1 and 30 degrees Celsius), ensuring it is not stored in excessively high or low temperatures.

Appearance

White, rectangular film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle