Medication info
Zyphen Tablets (Dexibuprofen D.C.)

Zyphen Tablets (Dexibuprofen D.C.)

Prescription medicationTabletOral
Ingredient · strength
Dexibuprofen D.C.›400mg / 1 tablet
Manufacturer / importer
Ilhwa Co., Ltd.
Appearance
White rectangular film-coated tablet
Packaging
30 tablets/bottle, 300 tablets/bottle
Approval status
Active

MFDS item code 200709249 · Notified 2007.08.08 · Insurance code 640901020

Summary

Main use
Joint disorders (arthritis, etc.), pain and inflammation after trauma or surgery, adjunctive treatment of infections
Who takes it
Adults
Adult dose
Adults: Administer 400 mg of dexibuprofen orally 2~3 times daily. However, do not exceed 1,200 mg of dexibuprofen per day.

Ingredients

Manufacturer
Ilhwa Co., Ltd.

Efficacy & effects

Joint disorders (arthritis, etc.), pain and inflammation after trauma or surgery, adjunctive treatment of infections

  • Chronic polyarthritis
  • rheumatoid arthritis
  • osteoarthritis
  • ankylosing spondylitis
  • pain and swelling after trauma and surgery
  • inflammation
  • pain
  • fever
View approved original text

This medication is used for chronic joint diseases such as chronic polyarthritis and rheumatoid arthritis, as well as for osteoarthritis and ankylosing spondylitis. It is also effective in relieving pain, swelling, and inflammation that occur after trauma or surgery. It helps improve the symptoms of infections accompanied by inflammation, pain, and fever.

How to take

Adult dose

Adults: Administer 400 mg of dexibuprofen orally 2~3 times daily. However, do not exceed 1,200 mg of dexibuprofen per day.

Precautions

This medication should be discussed with a doctor or pharmacist before use by individuals who regularly consume more than three alcoholic beverages per day, as it may cause gastrointestinal bleeding. This medication may increase the risk of cardiovascular disease; therefore, individuals with heart disease or risk factors should use it with caution. Doctors and patients should carefully monitor for any cardiovascular symptoms. This medication can cause serious gastrointestinal issues such as gastrointestinal bleeding, ulcers, or perforations, so it should be used with caution, especially in elderly patients or those with a history of gastrointestinal diseases. Any gastrointestinal symptoms during use should be reported to healthcare professionals immediately. Individuals with a history of gastrointestinal ulcers, bleeding, severe liver or kidney impairment, heart failure, hypertension, or asthma should not use this medication. Concomitant use of this medication with aspirin or other non-steroidal anti-inflammatory drugs should be avoided due to an increased risk of side effects. During treatment, it is recommended to stop breastfeeding or discontinue the medication if necessary. Caution is also advised when driving or operating machinery, as dizziness or fatigue may occur. Before using this medication, individuals with blood disorders, liver or kidney impairment, hypertension, heart failure, or a history of allergies should consult healthcare professionals. If severe skin rashes, shortness of breath, severe gastrointestinal symptoms, or neurological symptoms occur during use, the medication should be stopped immediately, and a doctor should be consulted. Use of this medication should be avoided, especially after six months of pregnancy, as it may affect the fetus. Women planning to become pregnant or who may be pregnant should discuss it with healthcare professionals. This medication should be used at the minimum effective dose for the shortest duration necessary, and regular blood tests and liver and kidney function tests should be conducted for long-term use. In case of overdose, appropriate medical treatment should be sought immediately, even if there are no symptoms. This medication should be kept out of reach of children, stored in a cool place away from direct sunlight and moisture, and should not be transferred to another container.

Side effects

Gastrointestinal bleeding, serious cardiovascular thrombotic reactions, myocardial infarction, stroke, bleeding from the stomach or intestines, ulcers, perforation, dyspepsia, abdominal distension, heartburn, upper abdominal pain, diarrhea, constipation, loss of appetite, nausea, vomiting, abdominal pain, gastric discomfort, esophagitis, esophageal stricture, diverticulitis exacerbation, nonspecific hemorrhagic colitis, ulcerative colitis, Crohn's disease, peptic ulcer gastric bleeding, perforation, bloody stools, gastritis, pancreatitis, thirst, stomatitis, erythema multiforme, systemic lupus erythematosus, alopecia, angioedema, skin-mucosal syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, eosinophilia, drug rash with systemic symptoms, acute generalized pustular psoriasis, rash, urticaria, pruritus, purpura, asthma attacks, eczema, anaphylaxis, photosensitivity reactions, jaundice, elevated ALT, elevated AST, elevated ALP, liver dysfunction, hepatitis, rhinitis, bronchospasm, acute pneumonia, neglect, cancer invasion, visual impairment, hearing loss, tinnitus, taste disturbances, fatigue, drowsiness, headache, dizziness, anxiety, restlessness, confusion, depression, aseptic meningitis, psychosis, agitation, excitement, spatial disorientation, reversible toxic amblyopia, hypotension, hypertension, palpitations, acute renal failure, oliguria, hematuria, increased protein in urine, increased BUN, elevated serum creatinine, hyperkalemia, decreased urine output, generalized edema, shortness of breath, lethargy, renal papillary necrosis, nephrotic syndrome, interstitial nephritis, peripheral edema, acute pulmonary edema, fluid retention, hypertension, heart failure, Kounis syndrome, decreased reproductive capacity in women, periorbital edema, malaise, fever, nosebleeds, exacerbation of inflammation, shouting, facial edema, dyspepsia, itching, anaphylactic shock, rash, diarrhea, vomiting

Not everyone experiences these, and they can vary from person to person.

Storage

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The appropriate storage temperature is between 1°C and 30°C, and it is advisable to avoid excessively hot or cold environments.

Appearance and packaging

Appearance

White rectangular film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.