Zatrosin XL Tablets (Alfuzosin Hydrochloride)

Adult dose

The recommended dose is 10mg once daily, taken immediately after the evening meal. Do not chew; swallow the tablet whole. When administered as adjunctive therapy to catheterization for acute urinary retention associated with benign prostatic hyperplasia, the recommended dose is 10mg once daily, taken after a meal starting on the first day of catheterization. Take for 2-3 days while the catheter is in place and for 1 day after catheter removal, for a total of 3-4 days.

This medication contains the ingredient alfuzosin, which should not be administered to certain patients. For instance, individuals allergic to this medication or its components, those with orthostatic hypotension, severely impaired liver function, very poor kidney function, bowel obstruction, those already taking another alpha-blocker, or those taking strong CYP3A4 inhibitors should not use this medicine. Additionally, some patients, particularly those on blood pressure medication, may experience symptoms of orthostatic hypotension when first taking this medicine. Symptoms such as dizziness, fatigue, and sweating may occur, so it is important to lie down and rest until the symptoms resolve. Older patients may experience these symptoms more prominently, so caution is advised. Patients with orthostatic hypotension, or those taking blood pressure medications or nitrate formulations should be more cautious when using this medication. Patients with coronary artery disease should not use this medicine alone, and if angina symptoms worsen, it should be discontinued immediately. Furthermore, individuals with prolonged QT interval or those taking medications that prolong QT interval should also use it cautiously. Taking this medication may result in side effects such as dizziness, headache, fainting, central nervous system abnormalities, tachycardia, and rarely angina, upper respiratory infections, nausea, abdominal pain, dyspepsia, constipation, skin rash, weakness, fatigue, erectile dysfunction, etc. Severe side effects like thrombocytopenia or liver damage have also been reported infrequently. Patients planning to undergo eye surgery must inform their physician that they are taking this medication, as it can cause a rare complication called intraoperative floppy iris syndrome during cataract surgery. The tablet should be swallowed whole, and crushing or chewing it may suddenly enhance its effects and increase the risk of side effects. This medication can cause severe hypotension when combined with other alpha-blockers, so caution is necessary. The risk of orthostatic hypotension may also increase when taken with antihypertensives or nitrate agents. Safety during pregnancy or breastfeeding has not been established, and there is no indication for use in children, nor has efficacy been proven in this age group. In the early stages of treatment, dizziness or weakness may occur, so caution is required during driving or operating machinery. In the event of an overdose, immediate hospitalization is necessary to maintain a lying position and receive treatment for hypotension, and this medication is difficult to remove through blood dialysis. Finally, this medication should be kept out of reach of children, and transferring it to another container may lead to accidents or a decline in quality, so care should be taken.

• Fainting
• dizziness
• headache
• lightheadedness
• syncope
• tachycardia
• angina
• atrial fibrillation
• intraoperative floppy iris syndrome
• upper respiratory tract infection

This medication should be stored in a tightly closed container to protect it from air and moisture, and it is best to keep it at room temperature between 1°C and 30°C. By adhering to appropriate storage conditions, the effectiveness of the medication can be maintained, and it can be used safely.

Appearance

This medication is a film-coated tablet with a total of three layers, consisting of one white layer sandwiched between two yellow layers, and is shaped as a convex round tablet.

Package unit

30 tablets/bottle, 100 tablets/bottle