Donepezil 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. For 4-6 weeks, administer a 5 mg dose, and after evaluating clinical responses, it can be increased to 10 mg. If increasing to 10 mg per day, pay attention to gastrointestinal adverse reactions. Underweight female patients aged 85 years and older should not exceed 5 mg per day and require careful monitoring.

Child dose

There is no experience of use in pediatric patients.

This medication is made with Donepezil Hydrochloride and is used in the treatment of symptoms of Alzheimer's type dementia. Firstly, this medicine should not be used by individuals allergic to Donepezil Hydrochloride or any of its components, women who are pregnant or may become pregnant, and women who are breastfeeding. Furthermore, since it contains lactose, it should not be administered to patients with genetic issues such as lactose intolerance or galactose intolerance. Precaution is needed for patients with heart disease or cardiac conduction disorders, those with a history of peptic ulcers or who are taking non-steroidal anti-inflammatory drugs, patients with a history of asthma or obstructive pulmonary disease, and those with extrapyramidal disorders such as Parkinson's disease. While taking this medication, severe adverse effects such as syncope, irregular heart beats, gastrointestinal bleeding, liver dysfunction, seizures, movement disorders, difficulty breathing, acute pancreatitis, acute kidney failure, etc., may occur. If such symptoms appear, consult a doctor immediately. Additionally, diverse adverse reactions such as nausea, vomiting, diarrhea, dizziness, insomnia, hallucinations, anxiety, muscle pain, blood pressure changes, etc., have been reported, requiring caution while taking this medication. Patients with heart disease need to be especially vigilant about the possibility of bradycardia and arrhythmias, which may necessitate an electrocardiogram. This medication may affect liver and kidney function, so regular examinations are recommended. Care should be taken while driving or operating machinery as dizziness or drowsiness may occur. Moreover, this medication can interact with various other drugs; therefore, consult a healthcare provider if you are taking other medications. Particularly, caution is needed when combined with drugs that affect the CYP3A4 and CYP2D6 enzymes, cardiac medications, and anti-inflammatory analgesics. It is recommended that pregnant or nursing women avoid using this medication; if necessary, consultation with a specialist is advised. Safety in children has not been established, so it is not used in pediatric patients. In the case of overdose, serious symptoms such as nausea, vomiting, decreased heart rate, and respiratory depression may appear. Immediate emergency care is required, and atropine may be used as an antidote. Finally, this medication should be stored out of reach of children and not transferred to another container for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, pain in oral/ocular mucosa, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), severe lethargy, sudden and severe headaches, lightning headaches, seizures, confusion, visual disturbances, paralysis, urination.

Mild side effects

• Cold
• loss of appetite
• hallucinations
• agitation
• aggressive behavior
• anxiety
• insomnia
• drowsiness
• increased libido
• talking excessively

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is recommended to be kept at room temperature between 1 degree and 30 degrees.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle