Neostil SR Tablets 4 mg (Tolterodine L-tartrate)

Adult dose

Adults: Administer 4 mg of tolterodine L-tartrate orally once daily. Patients with renal impairment, hepatic impairment, or receiving ketoconazole or another potent CYP3A4 inhibitor: Administer 2 mg of this medicine once daily. If adverse reactions occur, the dose may be reduced from 4 mg to 2 mg once daily. This medicine may be taken with or without food. Swallow the dosage form whole; do not crush or split it.

This medication should not be used in patients with urinary retention or gastric retention symptoms. Additionally, it should not be administered to patients with uncontrolled angle-closure glaucoma, allergy to this drug or its components, severe myasthenia gravis, severe ulcerative colitis, or toxic megacolon. Caution is warranted for patients with bladder outlet obstruction that may pose a risk of urinary retention, controlled angle-closure glaucoma, gastrointestinal obstructive diseases, or impaired kidney or liver function. Furthermore, it should be used carefully in patients taking strong CYP3A4 inhibitors, such as certain antibiotics or antifungals, patients with autonomic neuropathy, patients with hiatal hernia, and those at risk for decreased gastrointestinal motility. This medication may cause side effects such as dry mouth, dyspepsia, and reduced tears, and in rare cases, various adverse reactions have been reported, including confusion, drowsiness, dizziness, headaches, constipation, urinary difficulty, skin rash, etc. It may cause cardiac problems related to QT interval prolongation; therefore, special caution should be taken in patients with heart disease, electrolyte imbalances or those taking medications that prolong the QT interval. This medication may affect the ability to drive or operate machinery, so caution is advised during use. When used with other antimuscarinic drugs, effects may be enhanced, so consultation with a doctor is necessary, and careful attention should be paid when combined with certain enzyme inhibitors as it may increase drug concentration. Its safety has not been established in pregnant women; therefore, it is advisable not to use it. Fertile women should use adequate contraception. Breastfeeding women are also advised against using this medication. The safety and efficacy in children have not been sufficiently studied, so its use should be avoided. In case of overdose, serious side effects such as vision problems or urinary difficulty may occur, hence it is vital to seek medical attention immediately.

• Dry mouth
• indigestion
• decreased tear production
• bronchitis
• allergic reactions
• confusion
• drowsiness
• dizziness
• headache
• hypersensitivity

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is advisable to avoid direct sunlight and store it at cool room temperature of 25 degrees Celsius or lower.

Appearance

White, round, film-coated tablets

Package unit

30 tablets per bottle