JW Pharmaceutical Donepezil Tablet 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. Administer at the 5 mg dosage for 4 to 6 weeks, then evaluate the clinical response and may increase to 10 mg if necessary. When increasing to 10 mg per day, care should be taken regarding gastrointestinal adverse effects. Underweight women over 85 years should not exceed 5 mg per day and require careful monitoring.

Child dose

No experience with the use in pediatrics.

This drug is used for the treatment of Alzheimer's type dementia, with donepezil hydrochloride hydrate as the active ingredient. This medication should not be administered to certain patients, such as those with known allergies to this drug or any of its components, pregnant women or those who may become pregnant, and nursing mothers. Additionally, patients with genetic disorders affecting lactose should not be administered this drug. Patients with heart diseases or conduction disorders should be cautious when using this drug since it may slow heart rate or cause arrhythmias. Patients with a history of peptic ulcers or those taking non-steroidal anti-inflammatory drugs should also be cautious due to an increased risk of gastrointestinal bleeding. Those with asthma or obstructive pulmonary disease may experience exacerbation of symptoms when using this drug, so administration should be done carefully. This drug can affect the central nervous system and may induce or worsen extrapyramidal symptoms, so caution is advised when used in patients with Parkinson's disease. Furthermore, this drug contains the dye Tartrazine (Yellow No. 5), so patients with allergies to this component should be cautious as well. Various adverse reactions may occur while taking this drug. Cardiovascular issues may include syncope, bradycardia, heart block, and myocardial infarction. Gastrointestinal adverse effects may include peptic ulcers, gastrointestinal bleeding, nausea, vomiting, and diarrhea. Severe adverse reactions can also occur such as liver dysfunction, seizures, symptoms of extrapyramidal disorder, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, and acute kidney failure; therefore, immediate consultation with medical personnel should be sought in case of abnormal symptoms. This drug is approved only for use in Alzheimer's type dementia patients, and its use is not recommended for other types of dementia or memory decline. Treatment effects should be regularly evaluated, and if there is no effect, administration may be discontinued. Patients with cardiovascular diseases may need an electrocardiogram due to the risk of arrhythmias when taking this medication. Additionally, this drug may increase gastric acid secretion and worsen symptoms of peptic ulcers, so patients with a history of gastrointestinal disorders should be cautious. Since this medication can affect driving or machinery operation, caution should be exercised if dizziness or fatigue occurs at the beginning of the treatment. This drug can interact with various medications, so those taking other drugs must consult with their doctor or pharmacist. Special caution is needed when used in conjunction with heart-related medications, antibiotics, antidepressants, and antipsychotics. It is safe for pregnant or nursing women to avoid using this drug; if necessary, a decision should be made after consultation with a healthcare professional. The safety of this drug in children has not been established, so it should not be used in pediatrics. In case of overdose, serious side effects such as nausea, vomiting, bradycardia, hypotension, and respiratory depression may occur, requiring urgent medical care. This drug should be kept out of the reach of children and should not be transferred to another container to maintain quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, severe allergic reactions, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowish discoloration of skin or eyes (jaundice), profound lethargy, liver abnormalities (jaundice), sudden and severe headache.

Mild side effects

• Loss of appetite
• nausea
• vomiting
• diarrhea
• headache
• fatigue
• dizziness
• insomnia
• drowsiness
• fever

Store this medication in a tightly sealed container that is well-ventilated and ideally at temperatures between 1°C and 30°C. This way, the efficacy of the medication can be maintained and deterioration can be prevented.

Appearance

Yellow, round, film-coated tablet

Package unit

30 tablets/bottle