Glutazone (Pioglitazone Hydrochloride)

Adult dose

This medication is taken orally once daily, regardless of meals. For monotherapy, treatment can begin with an initial dose of 15 mg once daily, which can be increased to 30 mg once daily if sufficient efficacy is not achieved. For combination therapy, it is also given at 15 mg once daily and can be used in conjunction with sulfonylurea, metformin, or insulin. The maximum recommended dose is 30 mg once daily.

Child dose

There is no experience in using this drug in children under 18 years of age, so its use is not recommended.

This drug is used for the treatment of diabetes and has the effect of improving insulin resistance. Patients with heart disease such as congestive heart failure should not take this medication as it may exacerbate their condition. During treatment, patients should be closely monitored for sudden weight gain, shortness of breath, and swelling in the legs, and if these symptoms occur, they should consult a physician immediately. This medication can cause fluid retention, leading to edema, so patients with edema or at risk for heart disease should be especially cautious. Patients with a history of bladder cancer or those with active bladder cancer should not take this medication, and they should inform their doctor immediately if they experience bladder-related symptoms such as urinary difficulties or hematuria. Patients with impaired liver function or severe kidney disease also need to be cautious when taking this medication and should have regular liver and kidney function tests. The risk of hypoglycemia may increase when this drug is used in combination with other diabetes medications, so patients should be aware of the symptoms of hypoglycemia and how to manage them. Premenopausal women may have an increased chance of pregnancy as this drug may stimulate ovulation, so appropriate contraceptive measures should be taken. Elderly patients, those in poor nutritional status, individuals engaging in vigorous exercise, and excessive alcohol consumers should be cautious due to the risk of hypoglycemia. While taking this medication, patients should have regular blood sugar and liver function tests, and report any abnormal symptoms to medical personnel immediately. In the case of overdose, there may not be any specific symptoms, but appropriate treatment based on clinical symptoms is required. Safety has not been established for children or pregnant or breastfeeding women, so its use is not recommended. This medication should be kept out of the reach of children and stored in its original container.

Serious side effects

Congestive heart failure (including signs and symptoms such as edema, shortness of breath), worsening heart failure, cardiovascular abnormalities (myocardial infarction, cardiac failure), severe edema, bladder cancer, hospitalization due to hypoglycemia, liver abnormalities (including fatal and non-fatal liver failure, liver toxicity, symptoms of jaundice), severe neurological symptoms (stroke, seizures, etc.), severe allergic reactions (hives, severe swelling), shortness of breath, asthma attack, severe skin adverse reactions

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• muscle pain
• pharyngitis
• abdominal distension
• weight gain
• hypoglycemia
• urinary tract infection
• back pain

This medication must be stored in a tightly sealed container to prevent exposure to air and moisture. It is advisable to maintain the storage temperature between 1 degree and 30 degrees Celsius at room temperature. Proper storage helps preserve the effectiveness of the medication.

Appearance

White to grayish-white, convex cylindrical tablet

Package unit

30 tablets/bottle, 100 tablets/bottle