Pioglerone 15mg (Pioglitazone Hydrochloride)

Adult dose

This medication is administered orally once a day regardless of meals. As a monotherapy, it is initiated at 15 mg once a day, and if sufficient effect is not achieved, the dose may be increased to 30 mg once daily. For combination therapy, the initial dose is 15 mg once a day, and can be used with sulfonylureas, metformin, and insulin. The maximum recommended dose should not exceed 30 mg once daily.

Child dose

There is no experience in children under 18 years; therefore, administration is not recommended.

This medication helps to control blood sugar levels in patients with Type 2 diabetes and works by improving insulin resistance. During the course of treatment, caution is advised as this medication can put stress on the heart, particularly in patients with congestive heart failure or a history of congestive heart failure. Patients should be closely monitored for symptoms of heart failure such as sudden weight gain, shortness of breath, and swelling during treatment. This medication can cause fluid retention, which may worsen congestive heart failure; therefore, it should be used cautiously in patients with cardiovascular disease or swelling. Patients with active bladder cancer or a history of bladder cancer should not take this medication, and any symptoms such as hematuria or urinary disorders should be reported to a doctor immediately. Patients with impaired liver function or severe kidney dysfunction should also exercise caution while taking this medication. Women who are pregnant or may become pregnant should avoid this medication, and premenopausal women should use appropriate contraceptive methods as ovulation may be stimulated. This medication does not lower blood sugar levels when given alone and is effective only in the presence of insulin, hence it is not suitable for patients with Type 1 diabetes or diabetic ketoacidosis. Regular blood glucose and liver function tests should be conducted during treatment, and if any unusual symptoms arise, medical consultation is advised. Moreover, the risk of hypoglycemia may increase when this medication is used in conjunction with other hypoglycemic agents or insulin, so caution is necessary when combining therapies. Elderly patients or those with diminished kidney and liver function require careful monitoring while taking this medication. In the case of overdose, there is no specific antidote; thus, appropriate treatment based on symptoms is vital. Lastly, this medication has not been established for safety and effectiveness in children and should not be used in this population. This medication should be stored out of the reach of children and kept in its original container to maintain quality.

Serious side effects

Congestive heart failure, symptoms and signs of heart failure (excessive and rapid weight changes, breathlessness, swelling), severe swelling, bladder cancer, liver impairment and liver failure, jaundice, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweats, pallor), severe skin adverse reactions (severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa), breathing problems (shortness of breath or difficulty breathing)

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• myalgia
• pharyngitis
• abdominal bloating
• weight gain
• hypoglycemia
• urinary tract infection
• back pain

This medication should be stored in a container that can block light and air, and precautions should be taken to avoid exposure to moisture. Additionally, it is recommended to store it at temperatures between 15 to 30 degrees Celsius, especially around room temperature of approximately 25 degrees.

Appearance

White round tablet

Package unit

30 tablets/bottle