Rifenodine Tablets (Limaprost Alfadex)

Adult dose

1. For improvement of ischemic symptoms such as ulcers, pain, and coldness due to thromboangiitis obliterans (Buerger disease), the usual adult dosage is 2 tablets orally 3 times daily. 2. For improvement of subjective symptoms (lower limb pain and numbness) and walking ability due to acquired lumbar spinal canal stenosis (in patients with a normal SLR test and bilateral intermittent claudication), the usual adult dosage is 1 tablet orally 3 times daily. The dosage may be adjusted appropriately according to age and symptoms.

This drug should not be used in women who are pregnant or may become pregnant. Additionally, since this drug contains lactose, it should not be administered to patients with genetic issues such as lactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. It should be used cautiously in patients with bleeding tendencies or those taking antiplatelet agents, thrombolytics, or anticoagulants. While taking this medication, allergy symptoms such as rash or itching may occur, and if such symptoms appear, the medication should be stopped immediately. Also, bleeding may occur rarely; therefore, patients should be closely monitored for signs of bleeding. Gastrointestinal side effects may include diarrhea, nausea, abdominal discomfort, abdominal pain, decreased appetite, and heartburn. It may affect liver function, hence it is advisable to periodically check liver enzyme levels (AST, ALT). Symptoms of cardiovascular abnormalities such as palpitations, hypotension, and peripheral cyanosis may occur rarely. Other possible side effects include headaches, facial flushing, dizziness, feeling hot, generalized malaise, edema, breast swelling, tremors, hirsutism, and anemia. In patients with lumbar spinal canal stenosis, changes in symptoms should be closely monitored to determine whether to continue using this medication. The effect of this medication has not yet been sufficiently proven in patients with severe spinal canal stenosis. Safety during pregnancy has not been confirmed; animal studies have reported uterine contraction effects, so pregnant women should avoid taking this medication. Safety in children has not been established, and there is no experience of use. Elderly patients may have decreased bodily functions, so use should be cautious, such as by reducing the dose. Finally, when administered in large doses to healthy adults, temporary blood pressure drops may occur, so caution is necessary.

• Rash
• itching
• bleeding
• diarrhea
• nausea
• abdominal discomfort
• abdominal pain
• loss of appetite
• heartburn
• vomiting

This medication should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 degrees and 30 degrees Celsius. This way, the effectiveness and safety of the medication can be preserved for a long time.

Appearance

White round tablet

Package unit

84 tablets (21 tablets x 4)/Alu-Alu