Piolea 15 mg (Pioglitazone Hydrochloride)

Adult dose

This medication is taken orally once a day, regardless of meals. As monotherapy, it should be initiated at 15 mg once daily, and if insufficiently effective, it can be increased to 30 mg once daily. In combination therapy, 15 mg once daily is administered along with sulfonylureas, metformin, or insulin. The maximum recommended dose should not exceed 30 mg once daily.

Child dose

There is no experience with use in children under 18 years of age; therefore, administration is not recommended.

This medication is used to treat type 2 diabetes and helps enhance insulin action. However, it can put stress on the heart, so it should not be taken by patients with heart failure or a history of heart failure. During treatment, patients must be closely monitored for sudden weight gain, shortness of breath, or swelling in the legs that may indicate heart failure symptoms. If these symptoms occur, it may be necessary to immediately consult a doctor to adjust or discontinue the medication. This medication can also cause fluid retention and lead to edema, therefore patients with edema should be cautious when taking it. Active bladder cancer patients or those with a history of bladder cancer should not use this medication, and any symptoms of urinary dysfunction or hematuria should be reported to a doctor immediately. Patients with impaired liver function or severe kidney disease should also consult a physician before taking this medication. Women who are pregnant or may become pregnant should not take this medication, and premenopausal women should use appropriate contraception as this medication may stimulate ovulation and increase the risk of pregnancy. The risk of hypoglycemia may increase when this medication is used in combination with other diabetes treatments, so dose adjustments of the co-administered medications may be necessary. Additionally, regular monitoring of blood sugar and liver function tests should be conducted during the period of medication, and if any abnormal symptoms occur, healthcare professionals should be notified immediately. Elderly patients or those with decreased kidney function should also be cautious when using this medication. There may be no specific symptoms for overdose, but appropriate treatment should be provided based on any symptoms exhibited. Finally, this medication has not established safety and efficacy in children; thus, it should not be used in the pediatric population.

Serious side effects

Congestive heart failure, symptoms and signs of heart failure (including excessive and rapid weight change, difficulty breathing, edema), severe edema, urinary disorders, severe allergic reactions (urticaria), severe skin reactions (severe rash, blisters, skin peeling, mucosal pain in the mouth/eyes), liver abnormalities (jaundice, yellowing of the skin or eyes, systemic lethargy), serious neurological symptoms (sudden very severe headache, seizures, confusion, visual disturbances.

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• myalgia
• pharyngitis
• abdominal bloating
• weight gain
• hypoglycemia
• urinary tract infection
• back pain

This medication should be stored in a container that is protected from light and air, and in a cool place, ideally between 15 to 30 degrees Celsius, avoiding moist areas.

Appearance

This medication is a white, round tablet.

Package unit

30 tablets/bottle, 100 tablets/bottle