Aragan Plus Injection (Sodium Hyaluronate) (Prefilled Syringe)

Adult administration

Generally, for adults, 1 syringe is administered once a week for 3 weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or biceps tendon sheath), but the number of administrations may be adjusted according to symptoms.

This medication should not be used in patients who have had allergic reactions to its components. Patients with a history of allergies to other medications or those with liver function issues or past liver disorders should use it with caution. Additionally, caution is advised if there are skin diseases or infections at the injection site. When receiving this medication, severe allergic reactions such as shock may occur, so symptoms should be closely monitored, and usage should be immediately discontinued and treated if any issues arise. Symptoms of allergy such as swelling of the face or around the eyes, rash, or itching may occur; if such symptoms appear, drug administration should be stopped. Temporary pain, swelling, redness, warmth, or pressure may occur at the injection site, and rarely, severe pressure may be experienced. Nausea, vomiting, and fever may also occur, so attention is needed. This medication can worsen symptoms in joints with severe inflammation, so it is recommended to use it after the inflammation has subsided. After injection, care should be taken to stabilize the injection site and avoid overexertion. If the drug leaks outside the joint, pain may arise, so it must be accurately administered within the joint. It is very important to maintain aseptic conditions during injection, and if symptoms do not improve after three administrations, usage should be discontinued. If there is excessive joint fluid, it may be necessary to drain it before injection. This medication is not suitable for intravenous injection or use in the eyes. It is advisable to use a needle gauge of 22-23; some disinfectants may react and cause precipitation, so caution is advised. Women who are pregnant or may become pregnant should use this medication cautiously only when the benefits outweigh the risks, and breastfeeding should be avoided during administration. Safety has not been established in children, so it should only be used cautiously when absolutely necessary. Elderly patients may have diminished physiological functions, so it should be used with extra caution.

Serious side effects

Hives, swelling (facial, eyelid, etc.), shock symptoms (severe allergic reaction), abnormal AST, ALT levels (possible liver issues).

Mild side effects

Pain, swelling, redness, warmth, local pressure at the injection site, nausea, vomiting, fever, facial flushing, itching, rash, exacerbation of local inflammation symptoms, local pain, facial and eyelid swelling.

This medication should be stored in a sealed container to protect it from exposure to air and light. It is also best to store it at room temperature between 1°C and 30°C, avoiding direct sunlight.

Appearance

A colorless, transparent, and viscous liquid contained in a glass or plastic tube sealed with rubber stoppers at both ends (part of a prefilled syringe system).

Package unit

For domestic use - 3 prefilled syringes/box [(2 milliliters/prefilled syringe) × 3], for export - 1 prefilled syringe/box [(2 milliliters/prefilled syringe) × 1], for export - 3 prefilled syringes/box [(2 milliliters/prefilled syringe) × 3], for export - 10 prefilled syringes/box [(2 milliliters/prefilled syringe) × 10], for export - 1 prefilled syringe/box [(3 milliliters/prefilled syringe) × 1], for export - 3 prefilled syringes/box [(3 milliliters/prefilled syringe) × 3]