PioGlia Tablet (Pioglitazone Hydrochloride)

Adult dose

This medication is taken orally once daily, regardless of meals. Monotherapy may start at 15 mg once daily. If sufficient effect is not achieved with the initial dosage, it may be increased to 30 mg once daily. In combination therapy, it is administered as 15 mg once daily with sulfonylureas, metformin, or insulin. The maximum recommended dose does not exceed 30 mg once daily.

Child dose

There is no experience in use in children under 18 years, so its administration is not recommended.

This medication is used to treat type 2 diabetes and works by lowering blood sugar with the help of insulin. However, in some patients, it may put stress on the heart leading to congestive heart failure or worsen pre-existing heart failure, so it is important to carefully observe symptoms such as weight changes, shortness of breath, and edema after starting treatment. Patients with heart failure or a history of heart failure should not use this medication, and it is not recommended for symptomatic heart failure patients. This medication may cause fluid retention, and it should be used cautiously in patients at risk for heart failure. If symptoms such as hematuria, urinary disturbances, or urgency occur during treatment, it is important to inform a doctor immediately due to the possibility of bladder cancer. Additionally, it should not be administered to those with hypersensitivity to this medication, liver disorders, severe renal impairment, diabetic ketoacidosis, type 1 diabetes, patients with active or a history of bladder cancer, or women who are pregnant or may become pregnant. Patients currently taking other oral hypoglycemic agents, premenopausal women, patients with edema or cardiovascular disease, those with renal dysfunction, patients with poor nutritional status, those engaging in vigorous exercise, patients with excessive alcohol intake, and the elderly should use this medication with caution. Side effects of this medication may include edema, headache, upper respiratory infection, myalgia, weight gain, hypoglycemia, back pain, dizziness, diarrhea, elevated serum creatine kinase (CK), hypertension, chest pain, fatigue, weakness, dyspepsia, nausea, itching, chest discomfort, tremors, chills, gastrointestinal disorders, epigastric discomfort, numbness, rigidity, discomfort in the head, liver enzyme increase, worsening of liver disease, eczema, arthralgia, knee abnormalities. If liver dysfunction is suspected, regular liver function tests are necessary, and if symptoms of hepatitis or significantly elevated serum liver enzyme levels occur, treatment should be stopped immediately. Premenopausal women may experience increased chances of pregnancy due to ovulation stimulation while taking this medication, so adequate contraceptive methods should be used. This medication should be used cautiously during pregnancy, and whether to administer it to nursing mothers should be decided carefully. In cases of overdose, no specific symptoms may appear, but appropriate treatment should be provided according to clinical symptoms. This medication is not recommended for use in children and patients under 18 years of age as safety and efficacy have not been established. For the elderly, dose adjustment is not necessary, but careful monitoring is required. Lastly, this medication should be stored out of reach of children and kept in its original container.

Serious side effects

Congestive heart failure, symptoms of heart failure (including excessive and rapid weight changes, dyspnea, and edema), severe edema, cardiac failure, bladder cancer, liver abnormalities (jaundice, liver failure, elevated serum ALT and bilirubin levels), hypoglycemia (including cases of severe hypoglycemia leading to hospitalization), stroke, myocardial infarction, severe neurological symptoms, sudden and severe headache, seizure, confusion of consciousness, visual disturbances, paralysis, rash, severe allergy.

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• myalgia
• pharyngitis
• abdominal distension
• weight gain
• urinary tract infection
• hypoglycemia
• low back pain

This medication should be stored in a tightly closed container shielded from light and avoiding moist areas. The appropriate storage temperature is between 15 to 30 degrees Celsius, with approximately 25 degrees being the most suitable.

Appearance

White to grayish-white round and convex tablet

Package unit

30 tablets/bottle, 300 tablets/bottle