Benpra Tablet 20 mg (Rabeprazole Sodium)

Adult dose

For gastric ulcers and duodenal ulcers: typically 10 mg orally once daily; may increase to 20 mg orally once daily depending on symptoms. For erosive or ulcerative gastroesophageal reflux disease: administer 10 mg or 20 mg once daily for 4 to 8 weeks. If not resolved after 8 weeks, 10 mg or 20 mg may be taken orally twice daily for an additional 8 weeks. However, the 20 mg twice daily regimen is reserved for patients with severe mucosal damage. For relief of symptoms of gastroesophageal reflux disease: administer 10 mg once daily. If symptoms are not controlled after 4 weeks, further medical consultation is needed. Once symptoms have resolved, on-demand therapy with 10 mg once daily can be used to manage subsequent symptoms as needed. For long-term maintenance therapy of gastroesophageal reflux disease: patients may take 10 mg or 20 mg orally once daily depending on individual needs. For eradication of Helicobacter pylori: Patients infected with Helicobacter pylori should be treated with eradication therapy. It is recommended to administer this medication at 20 mg, together with clarithromycin 500 mg and amoxicillin 1 g, twice daily for 7 days. For Zollinger-Ellison syndrome: The recommended initial dose for adults is 60 mg once daily. The dose may be adjusted based on individual patient needs, up to 120 mg per day. For doses up to 100 mg, it can be administered once daily. The 120 mg dose is divided into two 60 mg doses taken twice daily. Patients with Zollinger-Ellison syndrome have been reported to receive this medication for up to 1 year. Caution in patients with liver dysfunction: Adverse reactions to hepatic encephalopathy have been reported in cirrhotic patients. Therefore, caution is warranted. Caution in pediatric patients: Safety in children has not been established. Caution in elderly patients: Due to frequent reduced liver function, caution should be exercised.

This medication should not be administered to patients allergic to specific components or who have shown hypersensitivity reactions to benzimidazole compounds. Patients allergic to penicillin or macrolide antibiotics should also exercise caution. It should not be used by pregnant or breastfeeding women, and should not be taken with certain antiviral agents. It should be used with caution in patients with impaired liver function, the elderly, or those with a history of drug allergies. This medication contains the pigment Yellow No. 4, so caution is advised for those allergic to this compound. If symptoms of an allergic reaction such as skin rash, urticaria, or itching occur during use, its use should be discontinued immediately. Regular blood tests may be necessary as red blood cell or white blood cell abnormalities can be found in laboratory tests. Symptoms of liver dysfunction may also appear, so liver function tests should be performed regularly. Caution is advised for those with cardiovascular disease as it may affect the heart and blood vessels. Gastrointestinal symptoms such as diarrhea, abdominal pain, nausea, and vomiting may occur. Central nervous system symptoms such as headache, insomnia, and dizziness should be monitored. Respiratory symptoms such as cough or dyspnea may occur rarely. Myalgia, arthralgia, skin rash, and itching have also been reported as adverse reactions. Vision abnormalities or hearing issues may occur rarely, so consult a specialist if any unusual symptoms arise. This medication strongly suppresses gastric acid secretion, potentially increasing the risk of osteoporosis and fractures with long-term use. Furthermore, prolonged use may lead to hypomagnesemia, requiring regular checks of magnesium levels in the blood. Reduced gastric acid may increase the risk of bacterial infections in the gastrointestinal tract, so notify your healthcare provider if diarrhea persists. Caution is required as drowsiness may occur while driving or operating machinery. This medication may interact with other drugs, so inform your healthcare provider of any medications being taken. There is no specific antidote for overdose, and appropriate treatment should be provided based on symptoms. Tablets should be swallowed whole and not chewed or crushed, and stored out of reach of children. It is safest not to use this medication in pregnant or nursing women. Elderly patients may have a higher risk of adverse reactions due to reduced liver function; they should discontinue use and consult a physician if symptoms arise. Safety in children has not been established, and experience is limited. If this medication is taken for a prolonged period, regular examinations to check for adverse reactions are important.

Serious side effects

Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness, acute hepatitis, liver dysfunction, jaundice, angina, myocardial infarction, ventricular tachycardia, pulmonary embolism, thrombophlebitis, deep vein thrombosis, ventricular fibrillation, Torsades de pointes, cardiac shock, severe allergic reactions, severe skin adverse reactions (toxic epidermal necrolysis, mucocutaneous syndrome, Stevens-Johnson syndrome), respiratory problems (asthma attack, rare dyspnea).

Mild side effects

• Rash
• urticaria
• itching
• decrease in red blood cells
• decrease in white blood cells
• increase in white blood cells
• increase in eosinophils
• increase in neutrophils
• decrease in lymphocytes
• anemia

This medication should be stored in a tightly sealed container protected from air and moisture. It is advisable to maintain storage temperatures between 1°C and 30°C at room temperature to preserve the effectiveness of the medication.

Appearance

Pale yellow round enteric-coated tablets

Package unit

28 tablets (14 tablets/PTP x 2)