PioVex Tablets 15 mg (Pioglitazone Hydrochloride)

Adult dose

This medication is taken orally once daily, regardless of meals. 1. Monotherapy This medication can be started as monotherapy at a dose of 15 mg once daily for patients whose blood sugar is not adequately controlled with diet and exercise. If the effect is insufficient, it may be increased to 30 mg once daily. 2. Combination Therapy When used in combination with sulfonylureas, metformin, or insulin, the initial dose is 15 mg once daily.

Child dose

There is no experience in using this medication in children under 18 years, therefore administration is not recommended.

This medication is an oral hypoglycemic agent used for the treatment of type 2 diabetes. This medication may cause or worsen congestive heart failure in some patients; thus, after starting treatment or increasing the dose, symptoms like weight changes, shortness of breath, and edema should be closely monitored. Patients with heart failure should not use this medication, and it is also not recommended for patients who exhibit symptoms of heart failure. When used with insulin, this medication can cause fluid retention, increasing the risk of heart failure; therefore, patients with a history of heart disease should exercise particular caution. Patients with bladder cancer or a history of it should not be administered this medication, and if hematuria or urinary disturbances occur during treatment, they must inform their doctor promptly. Patients with severely impaired liver function, severe kidney disease, diabetic ketoacidosis, type 1 diabetes, or women who are pregnant or may become pregnant should also avoid using this medication. While taking this medication, hypoglycemic symptoms may occur, particularly if used with other hypoglycemic agents such as insulin or sulfonylureas; therefore, medication dosage adjustments may be necessary to reduce the risk of hypoglycemia. Common side effects may include edema, weight gain, headache, and upper respiratory infections, while rare cases of liver function abnormalities or worsening heart failure have also been reported. During treatment, regular blood glucose and liver function tests should be conducted, and if any unusual symptoms arise, patients should consult their physician immediately. Premenopausal women should use adequate contraception as this medication may stimulate ovulation, increasing the risk of pregnancy. Elderly patients or those with decreased kidney function should also use this medication with caution, and dosage adjustments should be made at the physician's discretion. This medication is taken once daily; if a dose is missed, the next day should not include a double dose. Finally, safety and efficacy have not been established for use in children, thus it should not be administered to them.

Serious side effects

Congestive heart failure, symptoms and signs of heart failure (including excessive and rapid weight changes, shortness of breath, and edema), visible hematuria, urinary disturbances, urinary urgency, severe edema, liver dysfunction symptoms (fatigue, loss of appetite, discomfort in the right upper abdomen, dark urine, jaundice), fatal and non-fatal liver failure, severe edema or urinary abnormalities, severe allergic reactions (hives), serious neurological symptoms (stroke), jaundice, respiratory problems (shortness of breath)

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• myalgia
• pharyngitis
• abdominal bloating
• weight gain
• hypoglycemia
• urinary tract infection
• lower back pain

This medication should be stored in a container that protects from light and air, avoiding humid places. The storage temperature should be based on 25 degrees Celsius, but it is safe to store it between 15 to 30 degrees Celsius.

Appearance

Round, convex tablets that are white to grayish-white in color

Package unit

30 tablets/bottle, 100 tablets/bottle